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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Introcelluar Protein.
This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T52389
|
| Target Name |
NQO1
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
1728
|
| Gene ID |
100067237 (Equus caballus), 101097859 (Felis catus), 1728 (Homo sapiens), 18104 (Mus musculus) 24314 (Rattus norvegicus), 519632 (Bos taurus), 610935 (Canis lupus familiaris), 705635 (Macaca mulatta)
|
| Target Alternative Names |
Azoreductase,DHQU,DIA4,DT-diaphorase (DTD),DTD,Dia4,Dtd,Menadione reductase,NAD(P)H dehydrogenase [quinone] 1,NAD(P)H:quinone oxidoreductase 1,NMOR1,NMORI,NQO1,Nmo-1,Nmo1,Nmor1,Nqo1,Ox-1,Ox1,Phylloquinone reductase,QR1,Qr1,Quinone reductase 1 (QR1)
|
| Uniprot Accession |
P15559,Q64669,P05982
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
Metabolic pathways, Pathways in cancer, Hepatocellular carcinoma, Fluid shear stress and atherosclerosis
|
| Gene Ensembl |
ENSECAG00000020378, ENSG00000181019, ENSMUSG00000003849, ENSBTAG00000020632, ENSCAFG00845009149, ENSMMUG00000019684
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of NQO1 cDNA Clones/ORF Plasmid
NQO1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo1728 | Pre-made Human NQO1/DTD/QR1 siRNA oligo Duplex | 1728 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo24314 | Pre-made Rat Nqo1/Dia4 siRNA oligo Duplex | 24314 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo18104 | Pre-made Mouse Nqo1/Dtd/Ox1 siRNA oligo Duplex | 18104 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo705635 | Pre-made Cynomolgus/Rhesus macaque NQO1 siRNA oligo Duplex | 705635 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101097859 | Pre-made Cat/Feline NQO1 siRNA oligo Duplex | 101097859 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo610935 | Pre-made Dog/Canine NQO1 siRNA oligo Duplex | 610935 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo519632 | Pre-made Bovines/Cattle NQO1/DIA4 siRNA oligo Duplex | 519632 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100067237 | Pre-made Equine/Horse NQO1 siRNA oligo Duplex | 100067237 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
NQO1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T52389-Ab | Human | Anti-Human NQO1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T52389-Ab | Rat | Anti-Rat NQO1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T52389-Ab | Mouse | Anti-Mouse NQO1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T52389-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque NQO1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T52389-Ab | Cat/Feline | Anti-Cat/Feline NQO1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T52389-Ab | Dog/Canine | Anti-Dog/Canine NQO1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T52389-Ab | Bovines/Cattle | Anti-Bovines/Cattle NQO1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T52389-Ab | Equine/Horse | Anti-Equine/Horse NQO1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
NQO1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T52389-Ag | Human | Human NQO1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T52389-Ag | Rat | Rat NQO1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T52389-Ag | Mouse | Mouse NQO1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T52389-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque NQO1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T52389-Ag | Cat/Feline | Cat/Feline NQO1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T52389-Ag | Dog/Canine | Dog/Canine NQO1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T52389-Ag | Bovines/Cattle | Bovines/Cattle NQO1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T52389-Ag | Equine/Horse | Equine/Horse NQO1 recombinant protein | Mammalian cell | Detail |