Explore GM2A gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene encodes a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme beta-hexosaminidase A. Beta-hexosaminidase A, together with GM2 ganglioside activator, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in this gene result in GM2-gangliosidosis type AB or the AB variant of Tay-Sachs disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]
| Target ID |
GM-T51499
|
| Target Name |
GM2A
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
2760
|
| Gene ID |
100034082 (Equus caballus), 100174922 (Felis catus), 100855818 (Canis lupus familiaris), 14667 (Mus musculus)
2760 (Homo sapiens), 282838 (Rattus norvegicus), 504524 (Bos taurus), 713375 (Macaca mulatta)
|
| Target Alternative Names |
Cerebroside sulfate activator protein,GM2-AP,GM2A,GM2AP,Ganglioside GM2 activator,Gm2a,SAP-3,Sphingolipid activator protein 3 (SAP-3)
|
| Uniprot Accession |
Q60648,P17900
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target
|
| Disease |
Ovary Cancer
|
| Disease from KEGG |
Lysosome
|
| Gene Ensembl |
ENSECAG00000020587, ENSCAFG00845005428, ENSMUSG00000000594, ENSG00000196743, ENSBTAG00000021829, ENSMMUG00000022869
|
Pre-made viral vector of GM2A cDNA Clones/ORF Plasmid
GM2A siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo2760 | Pre-made Human GM2A/GM2AP/SAP-3 siRNA oligo Duplex | 2760 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo282838 | Pre-made Rat Gm2a siRNA oligo Duplex | 282838 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo14667 | Pre-made Mouse Gm2a/SAP-3/GM2-AP siRNA oligo Duplex | 14667 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo713375 | Pre-made Cynomolgus/Rhesus macaque GM2A siRNA oligo Duplex | 713375 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100174922 | Pre-made Cat/Feline GM2A siRNA oligo Duplex | 100174922 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100855818 | Pre-made Dog/Canine GM2A siRNA oligo Duplex | 100855818 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo504524 | Pre-made Bovines/Cattle GM2A siRNA oligo Duplex | 504524 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100034082 | Pre-made Equine/Horse GM2A siRNA oligo Duplex | 100034082 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
GM2A antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T51499-Ab | Human | Anti-Human GM2A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T51499-Ab | Rat | Anti-Rat GM2A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T51499-Ab | Mouse | Anti-Mouse GM2A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T51499-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque GM2A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T51499-Ab | Cat/Feline | Anti-Cat/Feline GM2A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T51499-Ab | Dog/Canine | Anti-Dog/Canine GM2A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T51499-Ab | Bovines/Cattle | Anti-Bovines/Cattle GM2A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T51499-Ab | Equine/Horse | Anti-Equine/Horse GM2A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM2A recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T51499-Ag | Human | Human GM2A recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T51499-Ag | Rat | Rat GM2A recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T51499-Ag | Mouse | Mouse GM2A recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T51499-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque GM2A recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T51499-Ag | Cat/Feline | Cat/Feline GM2A recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T51499-Ag | Dog/Canine | Dog/Canine GM2A recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T51499-Ag | Bovines/Cattle | Bovines/Cattle GM2A recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T51499-Ag | Equine/Horse | Equine/Horse GM2A recombinant protein | Mammalian cell | Detail |
