Explore EIF2AK2/PKR gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. The encoded protein plays an important role in the innate immune response against multiple DNA and RNA viruses. [provided by RefSeq, Jul 2021]
| Target ID |
GM-T51102
|
| Target Name |
EIF2AK2/PKR
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
5610
|
| Gene ID |
100147679 (Equus caballus), 101082744 (Felis catus), 19106 (Mus musculus), 347700 (Bos taurus)
54287 (Rattus norvegicus), 5610 (Homo sapiens), 611397 (Canis lupus familiaris), 708912 (Macaca mulatta)
|
| Target Alternative Names |
EIF2AK2,Eif2ak2,Pkr,Tik,Prkr,2310047A08Rik,4732414G15Rik,PKR,PRKR,DYT33,LEUDEN,EIF2AK1,PPP1R83
|
| Uniprot Accession |
Q03963,Q63184,P19525
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
|
| Disease |
|
| Disease from KEGG |
Protein processing in endoplasmic reticulum, Alzheimer disease, Hepatitis C, Measles, Influenza A, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Epstein-Barr virus infection
|
| Gene Ensembl |
ENSECAG00000011726, ENSMUSG00000024079, ENSBTAG00000008703, ENSG00000055332, ENSCAFG00845018782, ENSMMUG00000037522
|
| Target Classification |
Kinase
|
Pre-made viral vector of EIF2AK2/PKR cDNA Clones/ORF Plasmid
EIF2AK2/PKR siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo5610 | Pre-made Human EIF2AK2/PKR/PRKR siRNA oligo Duplex | 5610 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo54287 | Pre-made Rat Eif2ak2/Pkr/Prkr siRNA oligo Duplex | 54287 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo19106 | Pre-made Mouse Eif2ak2/Pkr/Tik siRNA oligo Duplex | 19106 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo708912 | Pre-made Cynomolgus/Rhesus macaque EIF2AK2 siRNA oligo Duplex | 708912 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101082744 | Pre-made Cat/Feline EIF2AK2 siRNA oligo Duplex | 101082744 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo611397 | Pre-made Dog/Canine EIF2AK2 siRNA oligo Duplex | 611397 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo347700 | Pre-made Bovines/Cattle EIF2AK2/PKR/PRKR siRNA oligo Duplex | 347700 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100147679 | Pre-made Equine/Horse EIF2AK2 siRNA oligo Duplex | 100147679 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
EIF2AK2/PKR antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T51102-Ab | Human | Anti-Human EIF2AK2/PKR monoclonal antibody | mab | | Detail |
| GM-Tg-rg-T51102-Ab | Rat | Anti-Rat EIF2AK2/PKR monoclonal antibody | mab | | Detail |
| GM-Tg-mg-T51102-Ab | Mouse | Anti-Mouse EIF2AK2/PKR monoclonal antibody | mab | | Detail |
| GM-Tg-cynog-T51102-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque EIF2AK2/PKR monoclonal antibody | mab | | Detail |
| GM-Tg-felg-T51102-Ab | Cat/Feline | Anti-Cat/Feline EIF2AK2/PKR monoclonal antibody | mab | | Detail |
| GM-Tg-cang-T51102-Ab | Dog/Canine | Anti-Dog/Canine EIF2AK2/PKR monoclonal antibody | mab | | Detail |
| GM-Tg-bovg-T51102-Ab | Bovines/Cattle | Anti-Bovines/Cattle EIF2AK2/PKR monoclonal antibody | mab | | Detail |
| GM-Tg-equg-T51102-Ab | Equine/Horse | Anti-Equine/Horse EIF2AK2/PKR monoclonal antibody | mab | | Detail |
EIF2AK2/PKR recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T51102-Ag | Human | Human EIF2AK2/PKR recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T51102-Ag | Rat | Rat EIF2AK2/PKR recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T51102-Ag | Mouse | Mouse EIF2AK2/PKR recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T51102-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque EIF2AK2/PKR recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T51102-Ag | Cat/Feline | Cat/Feline EIF2AK2/PKR recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T51102-Ag | Dog/Canine | Dog/Canine EIF2AK2/PKR recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T51102-Ag | Bovines/Cattle | Bovines/Cattle EIF2AK2/PKR recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T51102-Ag | Equine/Horse | Equine/Horse EIF2AK2/PKR recombinant protein | Mammalian cell | Detail |
