Explore TGFBR2 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes related to cell proliferation, cell cycle arrest, wound healing, immunosuppression, and tumorigenesis. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Aug 2017]
| Target ID |
GM-T49989
|
| Target Name |
TGFBR2
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
7048
|
| Gene ID |
100033860 (Equus caballus), 101091725 (Felis catus), 21813 (Mus musculus), 477039 (Canis lupus familiaris)
535376 (Bos taurus), 703088 (Macaca mulatta), 7048 (Homo sapiens), 81810 (Rattus norvegicus)
|
| Target Alternative Names |
1110020H15Rik,AAT3,DNIIR,FAA3,LDS1B,LDS2,LDS2B,MFS2,RIIC,RIIDN,TAAD2,TBETA-RII,TBR-II,TBR-ii,TBRII,TGF-beta 2,TGF-beta receptor type-2,TGF-beta type II receptor,TGFBR2,TGFBRII,TGFR-2,TGFbeta-RII,TbetaR-II,TbetaR-II),TbetaRII,Tgfbr2,Tgfbr2T,Transforming growth factor-beta receptor type II (TGF-beta receptor type II,tbetaR-II
|
| Uniprot Accession |
Q62312,P37173,P38438
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target, INN Index, Cytokine Target
|
| Disease |
cancer
|
| Disease from KEGG |
MAPK signaling pathway, Cytokine-cytokine receptor interaction, FoxO signaling pathway, Cellular senescence, TGF-beta signaling pathway, Osteoclast differentiation, Hippo signaling pathway, Adherens junction, Th17 cell differentiation, Relaxin signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Chagas disease, Hepatitis B, Human T-cell leukemia virus 1 infection, Pathways in cancer, Colorectal cancer, Pancreatic cancer, Chronic myeloid leukemia, Hepatocellular carcinoma, Gastric cancer
|
| Gene Ensembl |
ENSECAG00000015269, ENSMUSG00000032440, ENSCAFG00845022794, ENSBTAG00000019832, ENSMMUG00000010031, ENSG00000163513
|
| Target Classification |
Cytokine Receptor, Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA)
|
Pre-made viral vector of TGFBR2 cDNA Clones/ORF Plasmid
TGFBR2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo7048 | Pre-made Human TGFBR2/AAT3/FAA3 siRNA oligo Duplex | 7048 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo81810 | Pre-made Rat Tgfbr2/Tgfbr2T/TGF-beta 2 siRNA oligo Duplex | 81810 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo21813 | Pre-made Mouse Tgfbr2/DNIIR/RIIDN siRNA oligo Duplex | 21813 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo703088 | Pre-made Cynomolgus/Rhesus macaque TGFBR2 siRNA oligo Duplex | 703088 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101091725 | Pre-made Cat/Feline TGFBR2 siRNA oligo Duplex | 101091725 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo477039 | Pre-made Dog/Canine TGFBR2 siRNA oligo Duplex | 477039 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo535376 | Pre-made Bovines/Cattle TGFBR2 siRNA oligo Duplex | 535376 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100033860 | Pre-made Equine/Horse TGFBR2/TGFBRII/TBETA-RII siRNA oligo Duplex | 100033860 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
TGFBR2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T49989-Ab | Human | Anti-Human TGFBR2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-rg-T49989-Ab | Rat | Anti-Rat TGFBR2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-mg-T49989-Ab | Mouse | Anti-Mouse TGFBR2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-T49989-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque TGFBR2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-felg-T49989-Ab | Cat/Feline | Anti-Cat/Feline TGFBR2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cang-T49989-Ab | Dog/Canine | Anti-Dog/Canine TGFBR2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-T49989-Ab | Bovines/Cattle | Anti-Bovines/Cattle TGFBR2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-equg-T49989-Ab | Equine/Horse | Anti-Equine/Horse TGFBR2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
TGFBR2 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T49989-Ag | Human | Human TGFBR2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T49989-Ag | Rat | Rat TGFBR2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T49989-Ag | Mouse | Mouse TGFBR2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T49989-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque TGFBR2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T49989-Ag | Cat/Feline | Cat/Feline TGFBR2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T49989-Ag | Dog/Canine | Dog/Canine TGFBR2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T49989-Ag | Bovines/Cattle | Bovines/Cattle TGFBR2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T49989-Ag | Equine/Horse | Equine/Horse TGFBR2 VLP (virus-like particle) | HEK293 | Products Developing |
