Explore PTPN2 gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Transmembrane Protein.
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported. [provided by RefSeq, May 2011]
| Target ID |
GM-T49156
|
| Target Name |
PTPN2
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
5771
|
| Gene ID |
100057795 (Equus caballus), 101095923 (Felis catus), 114673846 (Macaca mulatta), 117063 (Rattus norvegicus) 19255 (Mus musculus), 490563 (Canis lupus familiaris), 540888 (Bos taurus), 5771 (Homo sapiens)
|
| Target Alternative Names |
PTN2,PTPN2,PTPT,Ptpn2,Ptpt,T-cell protein-tyrosine phosphatase (TCPTP),TC-PTP,TC45,TC48,TCELLPTP,TCPTP,Tyrosine-protein phosphatase non-receptor type 2
|
| Uniprot Accession |
P35233,Q06180,P17706
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
JAK-STAT signaling pathway
|
| Gene Ensembl |
ENSECAG00000000624, ENSMMUG00000055629, ENSMUSG00000024539, ENSCAFG00845005353, ENSBTAG00000010563, ENSG00000175354
|
Pre-made viral vector of PTPN2 cDNA Clones/ORF Plasmid
PTPN2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo5771 | Pre-made Human PTPN2/PTN2/PTPT siRNA oligo Duplex | 5771 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo117063 | Pre-made Rat Ptpn2 siRNA oligo Duplex | 117063 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo19255 | Pre-made Mouse Ptpn2/Ptpt/TC-PTP siRNA oligo Duplex | 19255 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo114673846 | Pre-made Cynomolgus/Rhesus macaque PTPN2 siRNA oligo Duplex | 114673846 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101095923 | Pre-made Cat/Feline PTPN2 siRNA oligo Duplex | 101095923 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo490563 | Pre-made Dog/Canine PTPN2 siRNA oligo Duplex | 490563 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo540888 | Pre-made Bovines/Cattle PTPN2 siRNA oligo Duplex | 540888 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100057795 | Pre-made Equine/Horse PTPN2 siRNA oligo Duplex | 100057795 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
PTPN2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T49156-Ab | Human | Anti-Human PTPN2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T49156-Ab | Rat | Anti-Rat PTPN2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T49156-Ab | Mouse | Anti-Mouse PTPN2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T49156-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque PTPN2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T49156-Ab | Cat/Feline | Anti-Cat/Feline PTPN2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T49156-Ab | Dog/Canine | Anti-Dog/Canine PTPN2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T49156-Ab | Bovines/Cattle | Anti-Bovines/Cattle PTPN2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T49156-Ab | Equine/Horse | Anti-Equine/Horse PTPN2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
PTPN2 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T49156-Ag | Human | Human PTPN2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T49156-Ag | Rat | Rat PTPN2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T49156-Ag | Mouse | Mouse PTPN2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T49156-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque PTPN2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T49156-Ag | Cat/Feline | Cat/Feline PTPN2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T49156-Ag | Dog/Canine | Dog/Canine PTPN2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T49156-Ag | Bovines/Cattle | Bovines/Cattle PTPN2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T49156-Ag | Equine/Horse | Equine/Horse PTPN2 VLP (virus-like particle) | HEK293 | Products Developing |