Explore HPSE gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Secreted Protein/Potential Cytokines.
Heparan sulfate proteoglycans are major components of the basement membrane and extracellular matrix. The protein encoded by this gene is an enzyme that cleaves heparan sulfate proteoglycans to permit cell movement through remodeling of the extracellular matrix. In addition, this cleavage can release bioactive molecules from the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
| Target ID |
GM-T47623
|
| Target Name |
HPSE
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
10855
|
| Gene ID |
100061267 (Equus caballus), 101090101 (Felis catus), 10855 (Homo sapiens), 15442 (Mus musculus)
281230 (Bos taurus), 608707 (Canis lupus familiaris), 64537 (Rattus norvegicus), 707583 (Macaca mulatta)
|
| Target Alternative Names |
Endo-glucoronidase,HPA,HPA1,HPR1,HPSE,HPSE1,HSE1,Hep,Heparanase,Heparanase-1 (Hpa1),Hpa,Hpr1,Hpse
|
| Uniprot Accession |
Q9Y251,Q6YGZ1,Q9MYY0,Q71RP1
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target, Immuno-oncology Target
|
| Disease |
cancer
|
| Disease from KEGG |
Metabolic pathways, Proteoglycans in cancer, Glycosaminoglycan degradation
|
| Gene Ensembl |
ENSECAG00000023599, ENSG00000173083, ENSMUSG00000035273, ENSBTAG00000005745, ENSCAFG00845021381, ENSMMUG00000013342
|
| Target Classification |
Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA)
|
Pre-made viral vector of HPSE cDNA Clones/ORF Plasmid
HPSE siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo10855 | Pre-made Human HPSE/HPA/HPA1 siRNA oligo Duplex | 10855 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo64537 | Pre-made Rat Hpse/Hep/Hpa siRNA oligo Duplex | 64537 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo15442 | Pre-made Mouse Hpse/Hpa/HSE1 siRNA oligo Duplex | 15442 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo707583 | Pre-made Cynomolgus/Rhesus macaque HPSE siRNA oligo Duplex | 707583 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101090101 | Pre-made Cat/Feline HPSE siRNA oligo Duplex | 101090101 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo608707 | Pre-made Dog/Canine HPSE siRNA oligo Duplex | 608707 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281230 | Pre-made Bovines/Cattle HPSE siRNA oligo Duplex | 281230 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100061267 | Pre-made Equine/Horse HPSE siRNA oligo Duplex | 100061267 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
HPSE antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T47623-Ab | Human | Anti-Human HPSE monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T47623-Ab | Rat | Anti-Rat HPSE monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T47623-Ab | Mouse | Anti-Mouse HPSE monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T47623-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque HPSE monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T47623-Ab | Cat/Feline | Anti-Cat/Feline HPSE monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T47623-Ab | Dog/Canine | Anti-Dog/Canine HPSE monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T47623-Ab | Bovines/Cattle | Anti-Bovines/Cattle HPSE monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T47623-Ab | Equine/Horse | Anti-Equine/Horse HPSE monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
HPSE recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T47623-Ag | Human | Human HPSE recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T47623-Ag | Rat | Rat HPSE recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T47623-Ag | Mouse | Mouse HPSE recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T47623-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque HPSE recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T47623-Ag | Cat/Feline | Cat/Feline HPSE recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T47623-Ag | Dog/Canine | Dog/Canine HPSE recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T47623-Ag | Bovines/Cattle | Bovines/Cattle HPSE recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T47623-Ag | Equine/Horse | Equine/Horse HPSE recombinant protein | Mammalian cell | Detail |
