TNFSF12/TWEAK Target & Gene Products-cDNA ORF clones/siRNA/antibody/protein

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Target sublocation: Transmembrane Protein.
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]

Pre-made viral vector of TNFSF12/TWEAK cDNA Clones/ORF Plasmid

TNFSF12/TWEAK siRNA/miRNA/oligo for RNA interfence (RNAi)

TNFSF12/TWEAK antibody/GMab

TNFSF12/TWEAK VLP (virus-like particle)