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Target
sublocation: Introcelluar Protein.
The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T43814
|
| Target Name |
TIRAP
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
114609
|
| Gene ID |
100064503 (Equus caballus), 101088688 (Felis catus), 114609 (Homo sapiens), 117149 (Mus musculus)
531079 (Bos taurus), 609544 (Canis lupus familiaris), 680127 (Rattus norvegicus), 714377 (Macaca mulatta)
|
| Target Alternative Names |
TIRAP,Tirap,Mal,wyatt,BACTS1,MyD88-2,Wyatt,Tlr4ap,C130027E04Rik
|
| Uniprot Accession |
P58753,Q99JY1
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
|
| Disease from KEGG |
NF-kappa B signaling pathway, Toll-like receptor signaling pathway, Alcoholic liver disease, Pathogenic Escherichia coli infection, Pertussis, Tuberculosis, Hepatitis B, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis
|
| Gene Ensembl |
ENSECAG00000049250, ENSG00000150455, ENSMUSG00000032041, ENSBTAG00000021504, ENSCAFG00845009385, ENSMMUG00000051458
|
| Target Classification |
|
Pre-made viral vector of TIRAP cDNA Clones/ORF Plasmid
TIRAP siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo114609 | Pre-made Human TIRAP/Mal/wyatt siRNA oligo Duplex | 114609 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo680127 | Pre-made Rat Tirap siRNA oligo Duplex | 680127 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo117149 | Pre-made Mouse Tirap/Mal/Wyatt siRNA oligo Duplex | 117149 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo714377 | Pre-made Cynomolgus/Rhesus macaque TIRAP siRNA oligo Duplex | 714377 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101088688 | Pre-made Cat/Feline TIRAP siRNA oligo Duplex | 101088688 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo609544 | Pre-made Dog/Canine TIRAP siRNA oligo Duplex | 609544 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo531079 | Pre-made Bovines/Cattle TIRAP siRNA oligo Duplex | 531079 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100064503 | Pre-made Equine/Horse TIRAP siRNA oligo Duplex | 100064503 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
TIRAP antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T43814-Ab | Human | Anti-Human TIRAP monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T43814-Ab | Rat | Anti-Rat TIRAP monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T43814-Ab | Mouse | Anti-Mouse TIRAP monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T43814-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque TIRAP monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T43814-Ab | Cat/Feline | Anti-Cat/Feline TIRAP monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T43814-Ab | Dog/Canine | Anti-Dog/Canine TIRAP monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T43814-Ab | Bovines/Cattle | Anti-Bovines/Cattle TIRAP monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T43814-Ab | Equine/Horse | Anti-Equine/Horse TIRAP monoclonal antibody | mab | Therapeutics Target antibody | Detail |
TIRAP recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T43814-Ag | Human | Human TIRAP recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T43814-Ag | Rat | Rat TIRAP recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T43814-Ag | Mouse | Mouse TIRAP recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T43814-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque TIRAP recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T43814-Ag | Cat/Feline | Cat/Feline TIRAP recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T43814-Ag | Dog/Canine | Dog/Canine TIRAP recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T43814-Ag | Bovines/Cattle | Bovines/Cattle TIRAP recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T43814-Ag | Equine/Horse | Equine/Horse TIRAP recombinant protein | Mammalian cell | Detail |
