Explore PLK1 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of this protein in cancer cells dramatically inhibited cell proliferation and induced apoptosis; hence, it is a target for cancer therapy. [provided by RefSeq, Sep 2015]
| Target ID |
GM-T40694
|
| Target Name |
PLK1
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
5347
|
| Gene ID |
100068388 (Equus caballus), 101098508 (Felis catus), 18817 (Mus musculus), 25515 (Rattus norvegicus) 489971 (Canis lupus familiaris), 5347 (Homo sapiens), 538238 (Bos taurus), 697686 (Macaca mulatta)
|
| Target Alternative Names |
PLK,PLK1,Plk,Plk1,Polo-like kinase 1 (PLK-1),STPK13,Serine/threonine-protein kinase 13 (STPK13),Serine/threonine-protein kinase PLK1
|
| Uniprot Accession |
Q07832,Q62673,P53350,Q2TA25
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
FoxO signaling pathway
|
| Gene Ensembl |
ENSECAG00000017777, ENSMUSG00000030867, ENSCAFG00845001570, ENSG00000166851, ENSBTAG00000014453, ENSMMUG00000017306
|
| Target Classification |
Kinase, Tumor-associated antigen (TAA)
|
Pre-made viral vector of PLK1 cDNA Clones/ORF Plasmid
PLK1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo5347 | Pre-made Human PLK1/PLK/STPK13 siRNA oligo Duplex | 5347 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25515 | Pre-made Rat Plk1/Plk siRNA oligo Duplex | 25515 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo18817 | Pre-made Mouse Plk1/Plk/STPK13 siRNA oligo Duplex | 18817 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo697686 | Pre-made Cynomolgus/Rhesus macaque PLK1 siRNA oligo Duplex | 697686 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101098508 | Pre-made Cat/Feline PLK1 siRNA oligo Duplex | 101098508 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo489971 | Pre-made Dog/Canine PLK1 siRNA oligo Duplex | 489971 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo538238 | Pre-made Bovines/Cattle PLK1 siRNA oligo Duplex | 538238 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100068388 | Pre-made Equine/Horse PLK1 siRNA oligo Duplex | 100068388 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
PLK1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T40694-Ab | Human | Anti-Human PLK1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T40694-Ab | Rat | Anti-Rat PLK1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T40694-Ab | Mouse | Anti-Mouse PLK1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T40694-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque PLK1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T40694-Ab | Cat/Feline | Anti-Cat/Feline PLK1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T40694-Ab | Dog/Canine | Anti-Dog/Canine PLK1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T40694-Ab | Bovines/Cattle | Anti-Bovines/Cattle PLK1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T40694-Ab | Equine/Horse | Anti-Equine/Horse PLK1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
PLK1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T40694-Ag | Human | Human PLK1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T40694-Ag | Rat | Rat PLK1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T40694-Ag | Mouse | Mouse PLK1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T40694-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque PLK1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T40694-Ag | Cat/Feline | Cat/Feline PLK1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T40694-Ag | Dog/Canine | Dog/Canine PLK1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T40694-Ag | Bovines/Cattle | Bovines/Cattle PLK1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T40694-Ag | Equine/Horse | Equine/Horse PLK1 recombinant protein | Mammalian cell | Detail |