Explore GAPDH gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The encoded protein has additionally been identified to have uracil DNA glycosylase activity in the nucleus. Also, this protein contains a peptide that has antimicrobial activity against E. coli, P. aeruginosa, and C. albicans. Studies of a similar protein in mouse have assigned a variety of additional functions including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferrin receptor on the cell surface of macrophage. Many pseudogenes similar to this locus are present in the human genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
| Target ID |
GM-T39321
|
| Target Name |
GAPDH
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
2597
|
| Gene ID |
100033897 (Equus caballus), 14433 (Mus musculus), 24383 (Rattus norvegicus), 2597 (Homo sapiens) 281181 (Bos taurus), 403755 (Canis lupus familiaris), 493876 (Felis catus), 574353 (Macaca mulatta)
|
| Target Alternative Names |
BARS-38,G3PD,G3PDH,GAPD,GAPDH,Gapd,Gapdh,Glyceraldehyde-3-phosphate dehydrogenase,HEL-S-162eP,Peptidyl-cysteine S-nitrosylase GAPDH
|
| Uniprot Accession |
P16858,P04797,P04406,P10096,Q28259,Q9N2D5
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
Metabolic pathways, HIF-1 signaling pathway, Alzheimer disease, Pathogenic Escherichia coli infection
|
| Gene Ensembl |
ENSECAG00000022051, ENSMUSG00000057666, ENSG00000111640, ENSBTAG00000014731, ENSCAFG00845028918, ENSMMUG00000018679
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of GAPDH cDNA Clones/ORF Plasmid
GAPDH siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo2597 | Pre-made Human GAPDH/G3PD/GAPD siRNA oligo Duplex | 2597 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo24383 | Pre-made Rat Gapdh/Gapd/BARS-38 siRNA oligo Duplex | 24383 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo14433 | Pre-made Mouse Gapdh/Gapd siRNA oligo Duplex | 14433 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo574353 | Pre-made Cynomolgus/Rhesus macaque GAPDH siRNA oligo Duplex | 574353 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo493876 | Pre-made Cat/Feline GAPDH siRNA oligo Duplex | 493876 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403755 | Pre-made Dog/Canine GAPDH siRNA oligo Duplex | 403755 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281181 | Pre-made Bovines/Cattle GAPDH/GAPD siRNA oligo Duplex | 281181 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100033897 | Pre-made Equine/Horse GAPDH/G3PDH siRNA oligo Duplex | 100033897 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
GAPDH antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T39321-Ab | Human | Anti-Human GAPDH monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T39321-Ab | Rat | Anti-Rat GAPDH monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T39321-Ab | Mouse | Anti-Mouse GAPDH monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T39321-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque GAPDH monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T39321-Ab | Cat/Feline | Anti-Cat/Feline GAPDH monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T39321-Ab | Dog/Canine | Anti-Dog/Canine GAPDH monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T39321-Ab | Bovines/Cattle | Anti-Bovines/Cattle GAPDH monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T39321-Ab | Equine/Horse | Anti-Equine/Horse GAPDH monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GAPDH VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T39321-Ag | Human | Human GAPDH VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T39321-Ag | Rat | Rat GAPDH VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T39321-Ag | Mouse | Mouse GAPDH VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T39321-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque GAPDH VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T39321-Ag | Cat/Feline | Cat/Feline GAPDH VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T39321-Ag | Dog/Canine | Dog/Canine GAPDH VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T39321-Ag | Bovines/Cattle | Bovines/Cattle GAPDH VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T39321-Ag | Equine/Horse | Equine/Horse GAPDH VLP (virus-like particle) | HEK293 | Products Developing |