Explore PAK1 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Mutations in this gene have been associated with macrocephaly, seizures, and speech delay. Overexpression of this gene is also reported in many cancer types, and particularly in breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2020]
| Target ID |
GM-T37961
|
| Target Name |
PAK1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
5058
|
| Gene ID |
100063217 (Equus caballus), 101087171 (Felis catus), 18479 (Mus musculus), 29431 (Rattus norvegicus)
5058 (Homo sapiens), 533729 (Bos taurus), 607885 (Canis lupus familiaris), 698585 (Macaca mulatta)
|
| Target Alternative Names |
Alpha-PAK,IDDMSSD,PAK-1,PAK1,PAKalpha,Pak1,Paka,Serine/threonine-protein kinase PAK 1,alpha-PAK,p21-activated kinase 1 (PAK-1),p65-PAK
|
| Uniprot Accession |
O88643,P35465,Q13153,Q08E52
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, cAMP signaling pathway, Chemokine signaling pathway, Axon guidance, Focal adhesion, C-type lectin receptor signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, Regulation of actin cytoskeleton, Epithelial cell signaling in Helicobacter pylori infection, Pathogenic Escherichia coli infection, Proteoglycans in cancer, Renal cell carcinoma
|
| Gene Ensembl |
ENSECAG00000017840, ENSMUSG00000030774, ENSG00000149269, ENSBTAG00000010191, ENSCAFG00845009162, ENSMMUG00000001387
|
| Target Classification |
Kinase, Tumor-associated antigen (TAA)
|
Pre-made viral vector of PAK1 cDNA Clones/ORF Plasmid
PAK1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo5058 | Pre-made Human PAK1/IDDMSSD/p65-PAK siRNA oligo Duplex | 5058 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo29431 | Pre-made Rat Pak1 siRNA oligo Duplex | 29431 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo18479 | Pre-made Mouse Pak1/Paka/PAK-1 siRNA oligo Duplex | 18479 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo698585 | Pre-made Cynomolgus/Rhesus macaque PAK1 siRNA oligo Duplex | 698585 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101087171 | Pre-made Cat/Feline PAK1 siRNA oligo Duplex | 101087171 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo607885 | Pre-made Dog/Canine PAK1 siRNA oligo Duplex | 607885 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo533729 | Pre-made Bovines/Cattle PAK1 siRNA oligo Duplex | 533729 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100063217 | Pre-made Equine/Horse PAK1 siRNA oligo Duplex | 100063217 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
PAK1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T37961-Ab | Human | Anti-Human PAK1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T37961-Ab | Rat | Anti-Rat PAK1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T37961-Ab | Mouse | Anti-Mouse PAK1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T37961-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque PAK1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T37961-Ab | Cat/Feline | Anti-Cat/Feline PAK1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T37961-Ab | Dog/Canine | Anti-Dog/Canine PAK1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T37961-Ab | Bovines/Cattle | Anti-Bovines/Cattle PAK1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T37961-Ab | Equine/Horse | Anti-Equine/Horse PAK1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
PAK1 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T37961-Ag | Human | Human PAK1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T37961-Ag | Rat | Rat PAK1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T37961-Ag | Mouse | Mouse PAK1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T37961-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque PAK1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T37961-Ag | Cat/Feline | Cat/Feline PAK1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T37961-Ag | Dog/Canine | Dog/Canine PAK1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T37961-Ag | Bovines/Cattle | Bovines/Cattle PAK1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T37961-Ag | Equine/Horse | Equine/Horse PAK1 VLP (virus-like particle) | HEK293 | Products Developing |
