Explore NOX2/CYBB gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T36729
|
| Target Name |
NOX2/CYBB
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
1536
|
| Gene ID |
100050132 (Equus caballus), 101086207 (Felis catus), 13058 (Mus musculus), 1536 (Homo sapiens)
281112 (Bos taurus), 491825 (Canis lupus familiaris), 66021 (Rattus norvegicus), 696542 (Macaca mulatta)
|
| Target Alternative Names |
AMCBX2,CGD,CGD91-phox,CGDX,CYBB,Cgd,Cybb,Cyd,Cytochrome b(558) subunit beta (Cytochrome b558 subunit beta),Cytochrome b-245 heavy chain,GP91-1,GP91-PHOX,GP91PHOX,Gp91-phox,Heme-binding membrane glycoprotein gp91phox,IMD34,NADPH oxidase 2,NOX2,Neutrophil cytochrome b 91 kDa polypeptide,Nox2,Superoxide-generating NADPH oxidase heavy chain subunit,gp91-1,gp91-phox,gp91phox,p22 phagocyte B-cytochrome,p91-PHOX
|
| Uniprot Accession |
Q61093,P04839,O46522
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
HIF-1 signaling pathway, Phagosome, Ferroptosis, NOD-like receptor signaling pathway, Leukocyte transendothelial migration, AGE-RAGE signaling pathway in diabetic complications, Alzheimer disease, Leishmaniasis, Lipid and atherosclerosis
|
| Gene Ensembl |
ENSECAG00000017917, ENSMUSG00000015340, ENSG00000165168, ENSBTAG00000019953, ENSCAFG00845023727, ENSMMUG00000013220
|
Pre-made viral vector of NOX2/CYBB cDNA Clones/ORF Plasmid
NOX2/CYBB siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo1536 | Pre-made Human CYBB/CGD/CGDX siRNA oligo Duplex | 1536 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo66021 | Pre-made Rat Cybb/Nox2/Gp91-phox siRNA oligo Duplex | 66021 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo13058 | Pre-made Mouse Cybb/Cgd/Cyd siRNA oligo Duplex | 13058 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo696542 | Pre-made Cynomolgus/Rhesus macaque CYBB siRNA oligo Duplex | 696542 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101086207 | Pre-made Cat/Feline CYBB siRNA oligo Duplex | 101086207 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo491825 | Pre-made Dog/Canine CYBB/NOX2 siRNA oligo Duplex | 491825 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281112 | Pre-made Bovines/Cattle CYBB/NOX2 siRNA oligo Duplex | 281112 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100050132 | Pre-made Equine/Horse CYBB siRNA oligo Duplex | 100050132 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
NOX2/CYBB antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T36729-Ab | Human | Anti-Human NOX2/CYBB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T36729-Ab | Rat | Anti-Rat NOX2/CYBB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T36729-Ab | Mouse | Anti-Mouse NOX2/CYBB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T36729-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque NOX2/CYBB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T36729-Ab | Cat/Feline | Anti-Cat/Feline NOX2/CYBB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T36729-Ab | Dog/Canine | Anti-Dog/Canine NOX2/CYBB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T36729-Ab | Bovines/Cattle | Anti-Bovines/Cattle NOX2/CYBB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T36729-Ab | Equine/Horse | Anti-Equine/Horse NOX2/CYBB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
NOX2/CYBB VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T36729-Ag | Human | Human NOX2/CYBB VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T36729-Ag | Rat | Rat NOX2/CYBB VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T36729-Ag | Mouse | Mouse NOX2/CYBB VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T36729-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque NOX2/CYBB VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T36729-Ag | Cat/Feline | Cat/Feline NOX2/CYBB VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T36729-Ag | Dog/Canine | Dog/Canine NOX2/CYBB VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T36729-Ag | Bovines/Cattle | Bovines/Cattle NOX2/CYBB VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T36729-Ag | Equine/Horse | Equine/Horse NOX2/CYBB VLP (virus-like particle) | HEK293 | Products Developing |
