MYC/c-MYC Target & Gene Products-cDNA ORF clones/siRNA/antibody/protein

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Target sublocation: Introcelluar Protein.
This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017]

Target ID	GM-T36121
Target Name	MYC/c-MYC
Gene Group ldentifer （Target Gene ID in Homo species)	4609
Gene ID	100068097 (Equus caballus), 100379628 (Felis catus), 17869 (Mus musculus), 24577 (Rattus norvegicus) 403924 (Canis lupus familiaris), 4609 (Homo sapiens), 511077 (Bos taurus), 694626 (Macaca mulatta)
Target Alternative Names	MYC,Myc,Myc2,Nird,Niard,bHLHe39,mMyc,c-myc,RNCMYC,MRTL,MYCC,C-MYC,v-myc,c-Myc,CMYC
Uniprot Accession	P68271,P01108,P09416,Q28350,P01106,Q2HJ27,B8XIA5
Uniprot Entry Name
Protein Sub-location	Introcelluar Protein
Category	Therapeutics Target
Disease	cancer, Breast Cancer, Lung Cancer, Lung cancer
Disease from KEGG	MAPK signaling pathway, ErbB signaling pathway, PI3K-Akt signaling pathway, Cellular senescence, Wnt signaling pathway, TGF-beta signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, JAK-STAT signaling pathway, Thyroid hormone signaling pathway, Hepatitis C, Hepatitis B, Human cytomegalovirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Epstein-Barr virus infection, Pathways in cancer, Proteoglycans in cancer, Chemical carcinogenesis - receptor activation, Colorectal cancer, Endometrial cancer, Thyroid cancer, Bladder cancer, Chronic myeloid leukemia, Acute myeloid leukemia, Small cell lung cancer, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Central carbon metabolism in cancer
Gene Ensembl	ENSECAG00000022059, ENSMUSG00000022346, ENSCAFG00845012475, ENSG00000136997, ENSBTAG00000008409, ENSMMUG00000014601
Target Classification	Pathway

Pre-made viral vector of MYC/c-MYC cDNA Clones/ORF Plasmid

Cat No.	Product Name	NMID	GeneID	Species	Type	Marker	Fusion Tag	Promoter	Detail
pGMLV000287	Human MYC/bHLHe39/c-Myc Lentivirus plasmid	NM_002467.5	4609	Human	Lentivirus plasmid	ZsGreen	3xflag (C-Terminal)	CMV	Detail
pGMLV000288	Human MYC/bHLHe39/c-Myc Lentivirus plasmid	NM_002467.4	4609	Human	Lentivirus plasmid	ZsGreen	3xflag (C-Terminal)	CMV	Detail
pGMLV000614	Human MYC/bHLHe39/c-Myc Lentivirus plasmid	NM_002467	4609	Human	Lentivirus plasmid	ZsGreen	3xflag (C-Terminal)	CMV	Detail
pGMLV002221	Human MYC/bHLHe39/c-Myc Lentivirus plasmid	NM_002467.4	4609	Human	Lentivirus plasmid	mCherry	3xflag (C-Terminal)	CMV	Detail
pGMAD000804	Human MYC/bHLHe39/c-Myc Adenovirus plasmid	NM_002467.6	4609	Human	Adenovirus plasmid	Null	3xflag (C-Terminal)	CMV	Detail
pGMAD001431	Human MYC/bHLHe39/c-Myc Adenovirus plasmid	NM_002467.6	4609	Human	Adenovirus plasmid	mCherry	HA (C-Terminal)	EF1	Detail
pGMAP000557	Human MYC/c-Myc Adenovirus plasmid	BC058901	4609	Human	Adenovirus plasmid	GFP	3xflag (C-Terminal)	EF1	Detail
pGMPC000377	Human MYC/bHLHe39/c-Myc Mammalian (Non-Viral Vector) plasmid	NM_002467.5	4609	Human	Mammalian (Non-Viral Vector) plasmid	EGFP	3xflag (C-Terminal)	EF1	Detail
vGMLV000287	Human MYC/bHLHe39/c-Myc Lentivirus particle	NM_002467.5	4609	Human	Lentivirus particle	ZsGreen	3xflag (C-Terminal)	CMV	Detail
vGMLV000288	Human MYC/bHLHe39/c-Myc Lentivirus particle	NM_002467.4	4609	Human	Lentivirus particle	ZsGreen	3xflag (C-Terminal)	CMV	Detail
vGMLV000614	Human MYC/bHLHe39/c-Myc Lentivirus particle	NM_002467	4609	Human	Lentivirus particle	ZsGreen	3xflag (C-Terminal)	CMV	Detail
vGMLV002221	Human MYC/bHLHe39/c-Myc Lentivirus particle	NM_002467.4	4609	Human	Lentivirus particle	mCherry	3xflag (C-Terminal)	CMV	Detail
vGMAD000804	Human MYC/bHLHe39/c-Myc Adenovirus particle	NM_002467.6	4609	Human	Adenovirus particle	Null	3xflag (C-Terminal)	CMV	Detail
vGMAD001431	Human MYC/bHLHe39/c-Myc Adenovirus particle	NM_002467.6	4609	Human	Adenovirus particle	mCherry	HA (C-Terminal)	EF1	Detail
vGMAP000557	Human MYC/c-Myc Adenovirus particle	BC058901	4609	Human	Adenovirus particle	GFP	3xflag (C-Terminal)	EF1	Detail

MYC/c-MYC siRNA/miRNA/oligo for RNA interfence (RNAi)

Cat No.	Product Name	GeneID	Species	Grade	Detail
pGMoligo4609	Pre-made Human MYC/MRTL/MYCC siRNA oligo Duplex	4609	Human	In-vitro grade; in-vivo grade	Detail
pGMoligo24577	Pre-made Rat Myc/mMyc/c-myc siRNA oligo Duplex	24577	Rat	In-vitro grade; in-vivo grade	Detail
pGMoligo17869	Pre-made Mouse Myc/Myc2/Nird siRNA oligo Duplex	17869	Mouse	In-vitro grade; in-vivo grade	Detail
pGMoligo694626	Pre-made Cynomolgus/Rhesus macaque MYC/c-Myc siRNA oligo Duplex	694626	Cynomolgus/Rhesus macaque	In-vitro grade; in-vivo grade	Detail
pGMoligo100379628	Pre-made Cat/Feline MYC siRNA oligo Duplex	100379628	Cat/Feline	In-vitro grade; in-vivo grade	Detail
pGMoligo403924	Pre-made Dog/Canine MYC/MRTL/MYCC siRNA oligo Duplex	403924	Dog/Canine	In-vitro grade; in-vivo grade	Detail
pGMoligo511077	Pre-made Bovines/Cattle MYC/CMYC siRNA oligo Duplex	511077	Bovines/Cattle	In-vitro grade; in-vivo grade	Detail
pGMoligo100068097	Pre-made Equine/Horse MYC siRNA oligo Duplex	100068097	Equine/Horse	In-vitro grade; in-vivo grade	Detail

MYC/c-MYC antibody/GMab

Cat No.	Species	Antibody Name	Format	Classified by tag	Detail
GM-Tg-hg-T36121-Ab	Human	Anti-Human MYC/c-MYC monoclonal antibody	mab	Therapeutics Target antibody	Detail
GM-Tg-rg-T36121-Ab	Rat	Anti-Rat MYC/c-MYC monoclonal antibody	mab	Therapeutics Target antibody	Detail
GM-Tg-mg-T36121-Ab	Mouse	Anti-Mouse MYC/c-MYC monoclonal antibody	mab	Therapeutics Target antibody	Detail
GM-Tg-cynog-T36121-Ab	Cynomolgus/Rhesus macaque	Anti-Cynomolgus/Rhesus macaque MYC/c-MYC monoclonal antibody	mab	Therapeutics Target antibody	Detail
GM-Tg-felg-T36121-Ab	Cat/Feline	Anti-Cat/Feline MYC/c-MYC monoclonal antibody	mab	Therapeutics Target antibody	Detail
GM-Tg-cang-T36121-Ab	Dog/Canine	Anti-Dog/Canine MYC/c-MYC monoclonal antibody	mab	Therapeutics Target antibody	Detail
GM-Tg-bovg-T36121-Ab	Bovines/Cattle	Anti-Bovines/Cattle MYC/c-MYC monoclonal antibody	mab	Therapeutics Target antibody	Detail
GM-Tg-equg-T36121-Ab	Equine/Horse	Anti-Equine/Horse MYC/c-MYC monoclonal antibody	mab	Therapeutics Target antibody	Detail

MYC/c-MYC recombinant protein

Cat No.	Species	Antigen Name	Expression Platform	Detail
GM-Tg-hg-T36121-Ag	Human	Human MYC/c-MYC recombinant protein	Mammalian cell	Detail
GM-Tg-rg-T36121-Ag	Rat	Rat MYC/c-MYC recombinant protein	Mammalian cell	Detail
GM-Tg-mg-T36121-Ag	Mouse	Mouse MYC/c-MYC recombinant protein	Mammalian cell	Detail
GM-Tg-cynog-T36121-Ag	Cynomolgus/Rhesus macaque	Cynomolgus/Rhesus macaque MYC/c-MYC recombinant protein	Mammalian cell	Detail
GM-Tg-felg-T36121-Ag	Cat/Feline	Cat/Feline MYC/c-MYC recombinant protein	Mammalian cell	Detail
GM-Tg-cang-T36121-Ag	Dog/Canine	Dog/Canine MYC/c-MYC recombinant protein	Mammalian cell	Detail
GM-Tg-bovg-T36121-Ag	Bovines/Cattle	Bovines/Cattle MYC/c-MYC recombinant protein	Mammalian cell	Detail
GM-Tg-equg-T36121-Ag	Equine/Horse	Equine/Horse MYC/c-MYC recombinant protein	Mammalian cell	Detail