Explore SMAD3 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
The SMAD family of proteins are a group of intracellular signal transducer proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. The SMAD3 protein functions in the transforming growth factor-beta signaling pathway, and transmits signals from the cell surface to the nucleus, regulating gene activity and cell proliferation. This protein forms a complex with other SMAD proteins and binds DNA, functioning both as a transcription factor and tumor suppressor. Mutations in this gene are associated with aneurysms-osteoarthritis syndrome and Loeys-Dietz Syndrome 3. [provided by RefSeq, May 2022]
| Target ID |
GM-T35445
|
| Target Name |
SMAD3
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
4088
|
| Gene ID |
100033845 (Equus caballus), 101101387 (Felis catus), 17127 (Mus musculus), 25631 (Rattus norvegicus)
4088 (Homo sapiens), 515125 (Bos taurus), 610902 (Canis lupus familiaris), 711355 (Macaca mulatta)
|
| Target Alternative Names |
HSPC193,HsT17436,JV15-2,LDS1C,LDS3,MAD homolog 3,MADH3,Mad3,Madh3,Mothers against DPP homolog 3,Mothers against decapentaplegic homolog 3,SMAD family member 3 (SMAD 3,SMAD3,Smad 3,Smad3,hMAD-3,hSMAD3,hSMAD3),mad3
|
| Uniprot Accession |
Q8BUN5,P84025,P84022
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target, Cytokine Target
|
| Disease |
cancer
|
| Disease from KEGG |
FoxO signaling pathway, Cellular senescence, Wnt signaling pathway, TGF-beta signaling pathway, Hippo signaling pathway, Adherens junction, Signaling pathways regulating pluripotency of stem cells, Th17 cell differentiation, AGE-RAGE signaling pathway in diabetic complications, Hepatitis B, Human T-cell leukemia virus 1 infection, Pathways in cancer, Colorectal cancer, Pancreatic cancer, Chronic myeloid leukemia, Hepatocellular carcinoma, Gastric cancer, Inflammatory bowel disease
|
| Gene Ensembl |
ENSMUSG00000032402, ENSG00000166949, ENSBTAG00000012599, ENSCAFG00845016639, ENSMMUG00000015455
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of SMAD3 cDNA Clones/ORF Plasmid
SMAD3 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo4088 | Pre-made Human SMAD3/LDS3/mad3 siRNA oligo Duplex | 4088 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25631 | Pre-made Rat Smad3/mad3/Madh3 siRNA oligo Duplex | 25631 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo17127 | Pre-made Mouse Smad3/Madh3 siRNA oligo Duplex | 17127 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo711355 | Pre-made Cynomolgus/Rhesus macaque SMAD3 siRNA oligo Duplex | 711355 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101101387 | Pre-made Cat/Feline SMAD3 siRNA oligo Duplex | 101101387 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo610902 | Pre-made Dog/Canine SMAD3/Madh3 siRNA oligo Duplex | 610902 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo515125 | Pre-made Bovines/Cattle SMAD3 siRNA oligo Duplex | 515125 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100033845 | Pre-made Equine/Horse SMAD3 siRNA oligo Duplex | 100033845 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
SMAD3 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T35445-Ab | Human | Anti-Human SMAD3 monoclonal antibody | mab | Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-rg-T35445-Ab | Rat | Anti-Rat SMAD3 monoclonal antibody | mab | Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-mg-T35445-Ab | Mouse | Anti-Mouse SMAD3 monoclonal antibody | mab | Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-T35445-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque SMAD3 monoclonal antibody | mab | Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-felg-T35445-Ab | Cat/Feline | Anti-Cat/Feline SMAD3 monoclonal antibody | mab | Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cang-T35445-Ab | Dog/Canine | Anti-Dog/Canine SMAD3 monoclonal antibody | mab | Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-T35445-Ab | Bovines/Cattle | Anti-Bovines/Cattle SMAD3 monoclonal antibody | mab | Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-equg-T35445-Ab | Equine/Horse | Anti-Equine/Horse SMAD3 monoclonal antibody | mab | Therapeutics Target antibody, Cytokine antibody | Detail |
SMAD3 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T35445-Ag | Human | Human SMAD3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T35445-Ag | Rat | Rat SMAD3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T35445-Ag | Mouse | Mouse SMAD3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T35445-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque SMAD3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T35445-Ag | Cat/Feline | Cat/Feline SMAD3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T35445-Ag | Dog/Canine | Dog/Canine SMAD3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T35445-Ag | Bovines/Cattle | Bovines/Cattle SMAD3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T35445-Ag | Equine/Horse | Equine/Horse SMAD3 recombinant protein | Mammalian cell | Detail |
