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Target
sublocation: Introcelluar Protein.
This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Aug 2011]
| Target ID |
GM-T35173
|
| Target Name |
cIAP2/BIRC3
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
330
|
| Gene ID |
100068894 (Equus caballus), 330 (Homo sapiens), 514386 (Bos taurus), 702468 (Macaca mulatta)
|
| Target Alternative Names |
AIP1,API2,Apoptosis inhibitor 2 (API2),BIRC2,BIRC3,Baculoviral IAP repeat-containing protein 3,CIAP2,Cellular inhibitor of apoptosis 2 (C-IAP2),HAIP1,HIAP1,IAP homolog C,IAP-1,Inhibitor of apoptosis protein 1 (hIAP-1,MALT2,MIHC,RING finger protein 49,RING-type E3 ubiquitin transferase BIRC3,RNF49,TNFR2-TRAF-signaling complex protein 1,c-IAP2,cIAP2,hIAP1)
|
| Uniprot Accession |
Q13489
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
NF-kappa B signaling pathway, Apoptosis, Apoptosis - multiple species, Hippo signaling pathway, Focal adhesion, NOD-like receptor signaling pathway, TNF signaling pathway, Toxoplasmosis, Pathways in cancer, Small cell lung cancer
|
| Gene Ensembl |
ENSECAG00000047232, ENSG00000023445, ENSBTAG00000024918, ENSMMUG00000058594
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of cIAP2/BIRC3 cDNA Clones/ORF Plasmid
cIAP2/BIRC3 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo330 | Pre-made Human BIRC3/AIP1/API2 siRNA oligo Duplex | 330 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo702468 | Pre-made Cynomolgus/Rhesus macaque BIRC3 siRNA oligo Duplex | 702468 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo514386 | Pre-made Bovines/Cattle BIRC3/BIRC2 siRNA oligo Duplex | 514386 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100068894 | Pre-made Equine/Horse BIRC3 siRNA oligo Duplex | 100068894 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
cIAP2/BIRC3 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T35173-Ab | Human | Anti-Human cIAP2/BIRC3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T35173-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque cIAP2/BIRC3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T35173-Ab | Bovines/Cattle | Anti-Bovines/Cattle cIAP2/BIRC3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T35173-Ab | Equine/Horse | Anti-Equine/Horse cIAP2/BIRC3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
cIAP2/BIRC3 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T35173-Ag | Human | Human cIAP2/BIRC3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T35173-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque cIAP2/BIRC3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T35173-Ag | Bovines/Cattle | Bovines/Cattle cIAP2/BIRC3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T35173-Ag | Equine/Horse | Equine/Horse cIAP2/BIRC3 recombinant protein | Mammalian cell | Detail |
