Explore IGFBP3 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T33455
|
| Target Name |
IGFBP3
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
3486
|
| Gene ID |
100034155 (Equus caballus), 100855619 (Canis lupus familiaris), 101080442 (Felis catus), 16009 (Mus musculus)
24484 (Rattus norvegicus), 282261 (Bos taurus), 3486 (Homo sapiens), 696868 (Macaca mulatta)
|
| Target Alternative Names |
BP-53,IBP-3,IBP3,IGF-BP3,IGF-binding protein 3,IGFBP-3,IGFBP3,IGgfbp3,Igfbp3,Insulin-like growth factor-binding protein 3
|
| Uniprot Accession |
P47878,P15473,P20959,P17936
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target, Cytokine Target
|
| Disease |
cancer, Ovary Cancer
|
| Disease from KEGG |
p53 signaling pathway, Cellular senescence, Growth hormone synthesis, secretion and action
|
| Gene Ensembl |
ENSECAG00000018104, ENSCAFG00845011212, ENSMUSG00000020427, ENSBTAG00000003994, ENSG00000146674, ENSMMUG00000013764
|
Pre-made viral vector of IGFBP3 cDNA Clones/ORF Plasmid
IGFBP3 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3486 | Pre-made Human IGFBP3/IBP3/BP-53 siRNA oligo Duplex | 3486 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo24484 | Pre-made Rat Igfbp3/IGF-BP3 siRNA oligo Duplex | 24484 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo16009 | Pre-made Mouse Igfbp3/IGFBP-3/IGgfbp3 siRNA oligo Duplex | 16009 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo696868 | Pre-made Cynomolgus/Rhesus macaque IGFBP3 siRNA oligo Duplex | 696868 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101080442 | Pre-made Cat/Feline IGFBP3 siRNA oligo Duplex | 101080442 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100855619 | Pre-made Dog/Canine IGFBP3 siRNA oligo Duplex | 100855619 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo282261 | Pre-made Bovines/Cattle IGFBP3/IGFBP-3 siRNA oligo Duplex | 282261 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100034155 | Pre-made Equine/Horse IGFBP3/IGFBP-3 siRNA oligo Duplex | 100034155 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
IGFBP3 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T33455-Ab | Human | Anti-Human IGFBP3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-rg-T33455-Ab | Rat | Anti-Rat IGFBP3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-mg-T33455-Ab | Mouse | Anti-Mouse IGFBP3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-T33455-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque IGFBP3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-felg-T33455-Ab | Cat/Feline | Anti-Cat/Feline IGFBP3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cang-T33455-Ab | Dog/Canine | Anti-Dog/Canine IGFBP3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-T33455-Ab | Bovines/Cattle | Anti-Bovines/Cattle IGFBP3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-equg-T33455-Ab | Equine/Horse | Anti-Equine/Horse IGFBP3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
IGFBP3 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T33455-Ag | Human | Human IGFBP3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T33455-Ag | Rat | Rat IGFBP3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T33455-Ag | Mouse | Mouse IGFBP3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T33455-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque IGFBP3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T33455-Ag | Cat/Feline | Cat/Feline IGFBP3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T33455-Ag | Dog/Canine | Dog/Canine IGFBP3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T33455-Ag | Bovines/Cattle | Bovines/Cattle IGFBP3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T33455-Ag | Equine/Horse | Equine/Horse IGFBP3 recombinant protein | Mammalian cell | Detail |
