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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes and binds to mannose and N-acetylglucosamine on many microorganisms, including bacteria, yeast, and viruses including influenza virus, HIV and SARS-CoV. This binding activates the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases. [provided by RefSeq, Jun 2020]
| Target ID |
GM-T32699
|
| Target Name |
MBL/MBL2
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
4153
|
| Gene ID |
100034103 (Equus caballus), 101100840 (Felis catus), 17195 (Mus musculus), 281297 (Bos taurus) 4153 (Homo sapiens), 64668 (Rattus norvegicus), 702652 (Macaca mulatta)
|
| Target Alternative Names |
Ab2-001,Ab2-011,COLEC1,Collectin-1,HSMBPC,L-MBP,MBL,MBL-C,MBL1,MBL2,MBL2D,MBP,MBP-C,MBP1,MBPD,Mannan-binding protein,Mannose-binding lectin,Mannose-binding protein C,Mbl2,RARF/P28A
|
| Uniprot Accession |
P41317,O02659,P11226,P08661
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
Phagosome, Complement and coagulation cascades, Staphylococcus aureus infection
|
| Gene Ensembl |
ENSECAG00000018357, ENSMUSG00000024863, ENSBTAG00000007049, ENSG00000165471, ENSMMUG00000046929
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of MBL/MBL2 cDNA Clones/ORF Plasmid
MBL/MBL2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo4153 | Pre-made Human MBL2/MBL/MBP siRNA oligo Duplex | 4153 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo64668 | Pre-made Rat Mbl2/Ab2-001/Ab2-011 siRNA oligo Duplex | 64668 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo17195 | Pre-made Mouse Mbl2/MBL/L-MBP siRNA oligo Duplex | 17195 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo702652 | Pre-made Cynomolgus/Rhesus macaque MBL2/MBP-C siRNA oligo Duplex | 702652 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101100840 | Pre-made Cat/Feline MBL1/MBL2 siRNA oligo Duplex | 101100840 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281297 | Pre-made Bovines/Cattle MBL2/MBL siRNA oligo Duplex | 281297 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100034103 | Pre-made Equine/Horse MBL2 siRNA oligo Duplex | 100034103 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
MBL/MBL2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T32699-Ab | Human | Anti-Human MBL/MBL2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T32699-Ab | Rat | Anti-Rat MBL/MBL2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T32699-Ab | Mouse | Anti-Mouse MBL/MBL2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T32699-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque MBL/MBL2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T32699-Ab | Cat/Feline | Anti-Cat/Feline MBL/MBL2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T32699-Ab | Bovines/Cattle | Anti-Bovines/Cattle MBL/MBL2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T32699-Ab | Equine/Horse | Anti-Equine/Horse MBL/MBL2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
MBL/MBL2 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T32699-Ag | Human | Human MBL/MBL2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T32699-Ag | Rat | Rat MBL/MBL2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T32699-Ag | Mouse | Mouse MBL/MBL2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T32699-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque MBL/MBL2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T32699-Ag | Cat/Feline | Cat/Feline MBL/MBL2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T32699-Ag | Bovines/Cattle | Bovines/Cattle MBL/MBL2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T32699-Ag | Equine/Horse | Equine/Horse MBL/MBL2 recombinant protein | Mammalian cell | Detail |