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Target
sublocation: Introcelluar Protein.
The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. Mutant beta globin causes sickle cell anemia. Absence of beta chain causes beta-zero-thalassemia. Reduced amounts of detectable beta globin causes beta-plus-thalassemia. The order of the genes in the beta-globin cluster is 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T31825
|
| Target Name |
HBB
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
3043
|
| Gene ID |
24440 (Rattus norvegicus), 3043 (Homo sapiens), 715559 (Macaca mulatta)
|
| Target Alternative Names |
Beta-globin,CD113t-C,ECYT6,HBB,Hbb,Hemoglobin beta chain,Hemoglobin subunit beta,beta-globin
|
| Uniprot Accession |
P02091,P68871,P02026
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
Malignant neoplasm of bladder, Complications of kidney transplant, IgA glomerulonephritis
|
| Disease from KEGG |
African trypanosomiasis, Malaria
|
| Gene Ensembl |
ENSG00000244734
|
Pre-made viral vector of HBB cDNA Clones/ORF Plasmid
HBB siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3043 | Pre-made Human HBB/ECYT6/CD113t-C siRNA oligo Duplex | 3043 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo24440 | Pre-made Rat Hbb siRNA oligo Duplex | 24440 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo715559 | Pre-made Cynomolgus/Rhesus macaque HBB siRNA oligo Duplex | 715559 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
HBB antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T31825-Ab | Human | Anti-Human HBB monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T31825-Ab | Rat | Anti-Rat HBB monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T31825-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque HBB monoclonal antibody | mab | Therapeutics Target antibody | Detail |
HBB recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T31825-Ag | Human | Human HBB recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T31825-Ag | Rat | Rat HBB recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T31825-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque HBB recombinant protein | Mammalian cell | Detail |