Explore EIF4E gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Introcelluar Protein.
The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
| Target ID |
GM-T31186
|
| Target Name |
EIF4E
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
1977
|
| Gene ID |
100066216 (Equus caballus), 101080377 (Felis catus), 117045 (Rattus norvegicus), 13684 (Mus musculus)
1977 (Homo sapiens), 281751 (Bos taurus), 487870 (Canis lupus familiaris), 706751 (Macaca mulatta)
|
| Target Alternative Names |
AUTS19,CBP,EG668879,EIF4E,EIF4E1,EIF4EL1,EIF4F,Eif4e,Eif4e-ps,Eukaryotic translation initiation factor 4E,If4e,eIF-4E,eIF-4F 25 kDa subunit,eIF4E,mRNA cap-binding protein
|
| Uniprot Accession |
P63074,P63073,P06730,Q9N0T5
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
EGFR tyrosine kinase inhibitor resistance, HIF-1 signaling pathway, PI3K-Akt signaling pathway, Longevity regulating pathway
|
| Gene Ensembl |
ENSECAG00000006472, ENSMUSG00000028156, ENSG00000151247, ENSBTAG00000009522, ENSCAFG00845023892, ENSMMUG00000011066
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of EIF4E cDNA Clones/ORF Plasmid
EIF4E siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo1977 | Pre-made Human EIF4E/CBP/EIF4F siRNA oligo Duplex | 1977 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo117045 | Pre-made Rat Eif4e siRNA oligo Duplex | 117045 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo13684 | Pre-made Mouse Eif4e/If4e/eIF-4E siRNA oligo Duplex | 13684 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo706751 | Pre-made Cynomolgus/Rhesus macaque EIF4E siRNA oligo Duplex | 706751 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101080377 | Pre-made Cat/Feline EIF4E siRNA oligo Duplex | 101080377 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo487870 | Pre-made Dog/Canine EIF4E siRNA oligo Duplex | 487870 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281751 | Pre-made Bovines/Cattle EIF4E siRNA oligo Duplex | 281751 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100066216 | Pre-made Equine/Horse EIF4E siRNA oligo Duplex | 100066216 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
EIF4E antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T31186-Ab | Human | Anti-Human EIF4E monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T31186-Ab | Rat | Anti-Rat EIF4E monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T31186-Ab | Mouse | Anti-Mouse EIF4E monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T31186-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque EIF4E monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T31186-Ab | Cat/Feline | Anti-Cat/Feline EIF4E monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T31186-Ab | Dog/Canine | Anti-Dog/Canine EIF4E monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T31186-Ab | Bovines/Cattle | Anti-Bovines/Cattle EIF4E monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T31186-Ab | Equine/Horse | Anti-Equine/Horse EIF4E monoclonal antibody | mab | Therapeutics Target antibody | Detail |
EIF4E recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T31186-Ag | Human | Human EIF4E recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T31186-Ag | Rat | Rat EIF4E recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T31186-Ag | Mouse | Mouse EIF4E recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T31186-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque EIF4E recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T31186-Ag | Cat/Feline | Cat/Feline EIF4E recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T31186-Ag | Dog/Canine | Dog/Canine EIF4E recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T31186-Ag | Bovines/Cattle | Bovines/Cattle EIF4E recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T31186-Ag | Equine/Horse | Equine/Horse EIF4E recombinant protein | Mammalian cell | Detail |
