Explore LIF gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Secreted Protein/Potential Cytokines.
The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
| Target ID |
GM-T29774
|
| Target Name |
LIF
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
3976
|
| Gene ID |
100629131 (Equus caballus), 101090296 (Felis catus), 16878 (Mus musculus), 280840 (Bos taurus)
3976 (Homo sapiens), 403449 (Canis lupus familiaris), 60584 (Rattus norvegicus), 715456 (Macaca mulatta)
|
| Target Alternative Names |
CDF,DIA,Differentiation-stimulating factor (D factor),HILDA,LIF,Leukemia inhibitory factor,Lif,MLPLI,Melanoma-derived LPL inhibitor (MLPLI)
|
| Uniprot Accession |
P09056,Q27956,P15018,P17777
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target, Cytokine Target
|
| Disease |
cancer
|
| Disease from KEGG |
Cytokine-cytokine receptor interaction, Signaling pathways regulating pluripotency of stem cells, JAK-STAT signaling pathway, TNF signaling pathway
|
| Gene Ensembl |
ENSECAG00000030554, ENSMUSG00000034394, ENSBTAG00000007424, ENSG00000128342, ENSCAFG00845030902, ENSMMUG00000048630
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of LIF cDNA Clones/ORF Plasmid
LIF siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3976 | Pre-made Human LIF/CDF/DIA siRNA oligo Duplex | 3976 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo60584 | Pre-made Rat Lif siRNA oligo Duplex | 60584 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo16878 | Pre-made Mouse Lif siRNA oligo Duplex | 16878 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo715456 | Pre-made Cynomolgus/Rhesus macaque LIF siRNA oligo Duplex | 715456 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101090296 | Pre-made Cat/Feline LIF siRNA oligo Duplex | 101090296 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403449 | Pre-made Dog/Canine LIF siRNA oligo Duplex | 403449 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo280840 | Pre-made Bovines/Cattle LIF siRNA oligo Duplex | 280840 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100629131 | Pre-made Equine/Horse LIF siRNA oligo Duplex | 100629131 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
LIF antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T29774-Ab | Human | Anti-Human LIF monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-rg-T29774-Ab | Rat | Anti-Rat LIF monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-mg-T29774-Ab | Mouse | Anti-Mouse LIF monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-T29774-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque LIF monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-felg-T29774-Ab | Cat/Feline | Anti-Cat/Feline LIF monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cang-T29774-Ab | Dog/Canine | Anti-Dog/Canine LIF monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-T29774-Ab | Bovines/Cattle | Anti-Bovines/Cattle LIF monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-equg-T29774-Ab | Equine/Horse | Anti-Equine/Horse LIF monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
LIF recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T29774-Ag | Human | Human LIF recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T29774-Ag | Rat | Rat LIF recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T29774-Ag | Mouse | Mouse LIF recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T29774-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque LIF recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T29774-Ag | Cat/Feline | Cat/Feline LIF recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T29774-Ag | Dog/Canine | Dog/Canine LIF recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T29774-Ag | Bovines/Cattle | Bovines/Cattle LIF recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T29774-Ag | Equine/Horse | Equine/Horse LIF recombinant protein | Mammalian cell | Detail |
