Explore GAD65/GAD2 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2008]
| Target ID |
GM-T22128
|
| Target Name |
GAD65/GAD2
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
2572
|
| Gene ID |
101082244 (Felis catus), 111772328 (Equus caballus), 14417 (Mus musculus), 24380 (Rattus norvegicus)
2572 (Homo sapiens), 487107 (Canis lupus familiaris), 512459 (Bos taurus), 613029 (Macaca mulatta)
|
| Target Alternative Names |
6330404F12Rik,65 kDa glutamic acid decarboxylase (GAD-65),GAD(65),GAD2,GAD65,Gad-2,Gad2,Glutamate decarboxylase 2,Glutamate decarboxylase 65 kDa isoform,gad65
|
| Uniprot Accession |
P48320,Q05683,Q05329,Q4PRC2
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Metabolic pathways, GABAergic synapse, Type I diabetes mellitus
|
| Gene Ensembl |
ENSECAG00000000006,ENSECAG00000039874, ENSMUSG00000026787, ENSG00000136750, ENSCAFG00845003895, ENSBTAG00000008056, ENSMMUG00000012233
|
Pre-made viral vector of GAD65/GAD2 cDNA Clones/ORF Plasmid
GAD65/GAD2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo2572 | Pre-made Human GAD2/GAD65 siRNA oligo Duplex | 2572 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo24380 | Pre-made Rat Gad2/gad65 siRNA oligo Duplex | 24380 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo14417 | Pre-made Mouse Gad2/GAD65/Gad-2 siRNA oligo Duplex | 14417 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo613029 | Pre-made Cynomolgus/Rhesus macaque GAD2/GAD65 siRNA oligo Duplex | 613029 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101082244 | Pre-made Cat/Feline GAD2 siRNA oligo Duplex | 101082244 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo487107 | Pre-made Dog/Canine GAD2/GAD65 siRNA oligo Duplex | 487107 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo512459 | Pre-made Bovines/Cattle GAD2 siRNA oligo Duplex | 512459 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo111772328 | Pre-made Equine/Horse GAD2 siRNA oligo Duplex | 111772328 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
GAD65/GAD2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T22128-Ab | Human | Anti-Human GAD65/GAD2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T22128-Ab | Rat | Anti-Rat GAD65/GAD2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T22128-Ab | Mouse | Anti-Mouse GAD65/GAD2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T22128-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque GAD65/GAD2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T22128-Ab | Cat/Feline | Anti-Cat/Feline GAD65/GAD2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T22128-Ab | Dog/Canine | Anti-Dog/Canine GAD65/GAD2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T22128-Ab | Bovines/Cattle | Anti-Bovines/Cattle GAD65/GAD2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T22128-Ab | Equine/Horse | Anti-Equine/Horse GAD65/GAD2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
GAD65/GAD2 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T22128-Ag | Human | Human GAD65/GAD2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T22128-Ag | Rat | Rat GAD65/GAD2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T22128-Ag | Mouse | Mouse GAD65/GAD2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T22128-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque GAD65/GAD2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T22128-Ag | Cat/Feline | Cat/Feline GAD65/GAD2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T22128-Ag | Dog/Canine | Dog/Canine GAD65/GAD2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T22128-Ag | Bovines/Cattle | Bovines/Cattle GAD65/GAD2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T22128-Ag | Equine/Horse | Equine/Horse GAD65/GAD2 recombinant protein | Mammalian cell | Detail |
