Explore Angiopoietin 2/ANGPT2 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
This gene belongs to the angiopoietin family of growth factors. The protein encoded by this gene is an antagonist of angiopoietin 1, and both angiopoietin 1 and angiopoietin 2 are ligands for the endothelial TEK receptor tyrosine kinase. Angiopoietin 2 is upregulated in multiple inflammatory diseases and is implicated in the direct control of inflammation-related signaling pathways. The encoded protein affects angiogenesis during embryogenesis and tumorigenesis, disrupts the vascular remodeling ability of angiopoietin 1, and may induce endothelial cell apoptosis. This gene serves a prognostic biomarker for acute respiratory distress syndrome. [provided by RefSeq, Aug 2020]
| Target ID |
GM-T21960
|
| Target Name |
Angiopoietin 2/ANGPT2
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
285
|
| Gene ID |
100051890 (Equus caballus), 102901787 (Felis catus), 11601 (Mus musculus), 282141 (Bos taurus)
285 (Homo sapiens), 607616 (Canis lupus familiaris), 716811 (Macaca mulatta), 89805 (Rattus norvegicus)
|
| Target Alternative Names |
AGPT2,ANG-2,ANG2,ANGPT2,Agpt2,Ang-2,Ang2,Angiopoietin 2,Angiopoietin-2,Angpt2,LMPHM10
|
| Uniprot Accession |
O35608,O77802,O15123,A0A8J8,O35462
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target, INN Index
|
| Disease |
cancer, breast cancer
|
| Disease from KEGG |
MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, PI3K-Akt signaling pathway, Kaposi sarcoma-associated herpesvirus infection
|
| Gene Ensembl |
ENSECAG00000015894, ENSMUSG00000031465, ENSBTAG00000011034, ENSG00000091879, ENSCAFG00845022531, ENSMMUG00000010139
|
| Target Classification |
Checkpoint-Immuno Oncology
|
Pre-made viral vector of Angiopoietin 2/ANGPT2 cDNA Clones/ORF Plasmid
Angiopoietin 2/ANGPT2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo285 | Pre-made Human ANGPT2/ANG2/AGPT2 siRNA oligo Duplex | 285 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo89805 | Pre-made Rat Angpt2/Agpt2/Ang-2 siRNA oligo Duplex | 89805 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo11601 | Pre-made Mouse Angpt2/Ang2/Agpt2 siRNA oligo Duplex | 11601 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo716811 | Pre-made Cynomolgus/Rhesus macaque ANGPT2 siRNA oligo Duplex | 716811 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo102901787 | Pre-made Cat/Feline ANGPT2 siRNA oligo Duplex | 102901787 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo607616 | Pre-made Dog/Canine ANGPT2/ANG-2 siRNA oligo Duplex | 607616 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo282141 | Pre-made Bovines/Cattle ANGPT2 siRNA oligo Duplex | 282141 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100051890 | Pre-made Equine/Horse ANGPT2 siRNA oligo Duplex | 100051890 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
Angiopoietin 2/ANGPT2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T21960-Ab | Human | Anti-Human Angiopoietin 2/ANGPT2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T21960-Ab | Rat | Anti-Rat Angiopoietin 2/ANGPT2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T21960-Ab | Mouse | Anti-Mouse Angiopoietin 2/ANGPT2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T21960-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque Angiopoietin 2/ANGPT2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T21960-Ab | Cat/Feline | Anti-Cat/Feline Angiopoietin 2/ANGPT2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T21960-Ab | Dog/Canine | Anti-Dog/Canine Angiopoietin 2/ANGPT2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T21960-Ab | Bovines/Cattle | Anti-Bovines/Cattle Angiopoietin 2/ANGPT2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T21960-Ab | Equine/Horse | Anti-Equine/Horse Angiopoietin 2/ANGPT2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
Angiopoietin 2/ANGPT2 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T21960-Ag | Human | Human Angiopoietin 2/ANGPT2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T21960-Ag | Rat | Rat Angiopoietin 2/ANGPT2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T21960-Ag | Mouse | Mouse Angiopoietin 2/ANGPT2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T21960-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque Angiopoietin 2/ANGPT2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T21960-Ag | Cat/Feline | Cat/Feline Angiopoietin 2/ANGPT2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T21960-Ag | Dog/Canine | Dog/Canine Angiopoietin 2/ANGPT2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T21960-Ag | Bovines/Cattle | Bovines/Cattle Angiopoietin 2/ANGPT2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T21960-Ag | Equine/Horse | Equine/Horse Angiopoietin 2/ANGPT2 VLP (virus-like particle) | HEK293 | Products Developing |
