Explore AVP gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene encodes a member of the vasopressin/oxytocin family and preproprotein that is proteolytically processed to generate multiple protein products. These products include the neuropeptide hormone arginine vasopressin, and two other peptides, neurophysin 2 and copeptin. Arginine vasopressin is a posterior pituitary hormone that is synthesized in the supraoptic nucleus and paraventricular nucleus of the hypothalamus. Along with its carrier protein, neurophysin 2, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis where it is either stored or secreted into the bloodstream. The precursor is thought to be activated while it is being transported along the axon to the posterior pituitary. Arginine vasopressin acts as a growth factor by enhancing pH regulation through acid-base transport systems. It has a direct antidiuretic action on the kidney, and also causes vasoconstriction of the peripheral vessels. This hormone can contract smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. Mutations in this gene cause autosomal dominant neurohypophyseal diabetes insipidus (ADNDI). This gene is present in a gene cluster with the related gene oxytocin on chromosome 20.
| Target ID |
GM-T20975
|
| Target Name |
AVP
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
551
|
| Gene ID |
100066842 (Equus caballus), 101096305 (Felis catus), 11998 (Mus musculus), 24221 (Rattus norvegicus) 280728 (Bos taurus), 403579 (Canis lupus familiaris), 551 (Homo sapiens), 717101 (Macaca mulatta)
|
| Target Alternative Names |
ADH,ARVP,AVP,AVP-NPII,AVRP,Avp,DI,VP,Vas,Vasopressin-neurophysin 2-copeptin,Vp,Vsp
|
| Uniprot Accession |
P01182,P35455,P01186,P01180,P01185
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction
|
| Gene Ensembl |
ENSMUSG00000037727, ENSBTAG00000008027, ENSCAFG00845015347, ENSG00000101200, ENSMMUG00000051923
|
Pre-made viral vector of AVP cDNA Clones/ORF Plasmid
AVP siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo551 | Pre-made Human AVP/VP/ADH siRNA oligo Duplex | 551 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo24221 | Pre-made Rat Avp/DI/VP siRNA oligo Duplex | 24221 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo11998 | Pre-made Mouse Avp/Vp/Vsp siRNA oligo Duplex | 11998 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo717101 | Pre-made Cynomolgus/Rhesus macaque AVP siRNA oligo Duplex | 717101 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101096305 | Pre-made Cat/Feline AVP siRNA oligo Duplex | 101096305 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403579 | Pre-made Dog/Canine AVP siRNA oligo Duplex | 403579 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo280728 | Pre-made Bovines/Cattle AVP/AVP-NPII siRNA oligo Duplex | 280728 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100066842 | Pre-made Equine/Horse AVP siRNA oligo Duplex | 100066842 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
AVP antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T20975-Ab | Human | Anti-Human AVP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T20975-Ab | Rat | Anti-Rat AVP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T20975-Ab | Mouse | Anti-Mouse AVP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T20975-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque AVP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T20975-Ab | Cat/Feline | Anti-Cat/Feline AVP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T20975-Ab | Dog/Canine | Anti-Dog/Canine AVP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T20975-Ab | Bovines/Cattle | Anti-Bovines/Cattle AVP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T20975-Ab | Equine/Horse | Anti-Equine/Horse AVP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
AVP recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T20975-Ag | Human | Human AVP recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T20975-Ag | Rat | Rat AVP recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T20975-Ag | Mouse | Mouse AVP recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T20975-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque AVP recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T20975-Ag | Cat/Feline | Cat/Feline AVP recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T20975-Ag | Dog/Canine | Dog/Canine AVP recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T20975-Ag | Bovines/Cattle | Bovines/Cattle AVP recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T20975-Ag | Equine/Horse | Equine/Horse AVP recombinant protein | Mammalian cell | Detail |