Explore ALAD gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
| Target ID |
GM-T20514
|
| Target Name |
ALAD
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
210
|
| Gene ID |
100052763 (Equus caballus), 101096680 (Felis catus), 17025 (Mus musculus), 210 (Homo sapiens)
25374 (Rattus norvegicus), 474808 (Canis lupus familiaris), 510679 (Bos taurus), 705193 (Macaca mulatta)
|
| Target Alternative Names |
ALAD,ALADH,ALADR,Alad,Delta-aminolevulinic acid dehydratase,Lv,PBGS,Porphobilinogen synthase
|
| Uniprot Accession |
P10518,P13716,P06214,Q58DK5
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Metabolic pathways, Porphyrin metabolism
|
| Gene Ensembl |
ENSECAG00000015427, ENSMUSG00000028393, ENSG00000148218, ENSCAFG00845007987, ENSBTAG00000000251, ENSMMUG00000031965
|
Pre-made viral vector of ALAD cDNA Clones/ORF Plasmid
ALAD siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo210 | Pre-made Human ALAD/PBGS/ALADH siRNA oligo Duplex | 210 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25374 | Pre-made Rat Alad/ALADH/ALADR siRNA oligo Duplex | 25374 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo17025 | Pre-made Mouse Alad/Lv/ALADH siRNA oligo Duplex | 17025 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo705193 | Pre-made Cynomolgus/Rhesus macaque ALAD siRNA oligo Duplex | 705193 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101096680 | Pre-made Cat/Feline ALAD siRNA oligo Duplex | 101096680 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo474808 | Pre-made Dog/Canine ALAD siRNA oligo Duplex | 474808 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo510679 | Pre-made Bovines/Cattle ALAD siRNA oligo Duplex | 510679 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100052763 | Pre-made Equine/Horse ALAD siRNA oligo Duplex | 100052763 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
ALAD antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T20514-Ab | Human | Anti-Human ALAD monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T20514-Ab | Rat | Anti-Rat ALAD monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T20514-Ab | Mouse | Anti-Mouse ALAD monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T20514-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque ALAD monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T20514-Ab | Cat/Feline | Anti-Cat/Feline ALAD monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T20514-Ab | Dog/Canine | Anti-Dog/Canine ALAD monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T20514-Ab | Bovines/Cattle | Anti-Bovines/Cattle ALAD monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T20514-Ab | Equine/Horse | Anti-Equine/Horse ALAD monoclonal antibody | mab | Therapeutics Target antibody | Detail |
ALAD recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T20514-Ag | Human | Human ALAD recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T20514-Ag | Rat | Rat ALAD recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T20514-Ag | Mouse | Mouse ALAD recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T20514-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque ALAD recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T20514-Ag | Cat/Feline | Cat/Feline ALAD recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T20514-Ag | Dog/Canine | Dog/Canine ALAD recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T20514-Ag | Bovines/Cattle | Bovines/Cattle ALAD recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T20514-Ag | Equine/Horse | Equine/Horse ALAD recombinant protein | Mammalian cell | Detail |
