Explore MEK5/MAP2K5 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011]
| Target ID |
GM-T17143
|
| Target Name |
MEK5/MAP2K5
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
5607
|
| Gene ID |
100052849 (Equus caballus), 100295732 (Bos taurus), 101100725 (Felis catus), 23938 (Mus musculus)
29568 (Rattus norvegicus), 5607 (Homo sapiens), 609559 (Canis lupus familiaris), 711672 (Macaca mulatta)
|
| Target Alternative Names |
Dual specificity mitogen-activated protein kinase kinase 5,HsT17454,MAP kinase kinase 5,MAP2K5,MAPK/ERK kinase 5 (MEK 5),MAPKK 5,MAPKK5,MEK5,Map2k5,Mapkk5,Mek5,PRKMK5,Prkmk5
|
| Uniprot Accession |
Q9WVS7,Q62862,Q13163
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
MAPK signaling pathway, Gap junction, Neurotrophin signaling pathway, Oxytocin signaling pathway, Fluid shear stress and atherosclerosis
|
| Gene Ensembl |
ENSECAG00000022411, ENSBTAG00000000218, ENSMUSG00000058444, ENSG00000137764, ENSCAFG00845017514, ENSMMUG00000014482
|
Pre-made viral vector of MEK5/MAP2K5 cDNA Clones/ORF Plasmid
MEK5/MAP2K5 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo5607 | Pre-made Human MAP2K5/MEK5/MAPKK5 siRNA oligo Duplex | 5607 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo29568 | Pre-made Rat Map2k5/Mek5 siRNA oligo Duplex | 29568 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo23938 | Pre-made Mouse Map2k5/MEK5/Mapkk5 siRNA oligo Duplex | 23938 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo711672 | Pre-made Cynomolgus/Rhesus macaque MAP2K5 siRNA oligo Duplex | 711672 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101100725 | Pre-made Cat/Feline MAP2K5 siRNA oligo Duplex | 101100725 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo609559 | Pre-made Dog/Canine MAP2K5 siRNA oligo Duplex | 609559 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100295732 | Pre-made Bovines/Cattle MAP2K5 siRNA oligo Duplex | 100295732 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100052849 | Pre-made Equine/Horse MAP2K5 siRNA oligo Duplex | 100052849 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
MEK5/MAP2K5 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T17143-Ab | Human | Anti-Human MEK5/MAP2K5 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T17143-Ab | Rat | Anti-Rat MEK5/MAP2K5 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T17143-Ab | Mouse | Anti-Mouse MEK5/MAP2K5 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T17143-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque MEK5/MAP2K5 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T17143-Ab | Cat/Feline | Anti-Cat/Feline MEK5/MAP2K5 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T17143-Ab | Dog/Canine | Anti-Dog/Canine MEK5/MAP2K5 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T17143-Ab | Bovines/Cattle | Anti-Bovines/Cattle MEK5/MAP2K5 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T17143-Ab | Equine/Horse | Anti-Equine/Horse MEK5/MAP2K5 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
MEK5/MAP2K5 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T17143-Ag | Human | Human MEK5/MAP2K5 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T17143-Ag | Rat | Rat MEK5/MAP2K5 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T17143-Ag | Mouse | Mouse MEK5/MAP2K5 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T17143-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque MEK5/MAP2K5 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T17143-Ag | Cat/Feline | Cat/Feline MEK5/MAP2K5 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T17143-Ag | Dog/Canine | Dog/Canine MEK5/MAP2K5 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T17143-Ag | Bovines/Cattle | Bovines/Cattle MEK5/MAP2K5 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T17143-Ag | Equine/Horse | Equine/Horse MEK5/MAP2K5 recombinant protein | Mammalian cell | Detail |
