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Target
sublocation: Transmembrane Protein.
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jan 2015]
| Target ID |
GM-T15783
|
| Target Name |
NKG2A/KLRC1/CD159a
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
3821
|
| Gene ID |
29683 (Rattus norvegicus), 3821 (Homo sapiens), 574146 (Macaca mulatta)
|
| Target Alternative Names |
CD159 antigen-like family member A,CD159A,CD159a,KLRC1,Klrc1,NK cell receptor A,NKG2,NKG2-A,NKG2-A/B-activating NK receptor,NKG2-A/NKG2-B type II integral membrane protein,NKG2A,rNKG2A
|
| Uniprot Accession |
P26715,Q9MZJ3
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target, INN Index
|
| Disease from KEGG |
Antigen processing and presentation, Natural killer cell mediated cytotoxicity, Graft-versus-host disease
|
| Gene Ensembl |
ENSG00000134545
|
| Target Classification |
Checkpoint-Immuno Oncology
|
Pre-made viral vector of NKG2A/KLRC1/CD159a cDNA Clones/ORF Plasmid
NKG2A/KLRC1/CD159a siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3821 | Pre-made Human KLRC1/NKG2/NKG2A siRNA oligo Duplex | 3821 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo29683 | Pre-made Rat Klrc1/rNKG2A siRNA oligo Duplex | 29683 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo574146 | Pre-made Cynomolgus/Rhesus macaque KLRC1/NKG2A/CD159a siRNA oligo Duplex | 574146 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
NKG2A/KLRC1/CD159a antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T15783-Ab | Human | Anti-Human NKG2A/KLRC1/CD159a monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T15783-Ab | Rat | Anti-Rat NKG2A/KLRC1/CD159a monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T15783-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque NKG2A/KLRC1/CD159a monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
NKG2A/KLRC1/CD159a VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T15783-Ag | Human | Human NKG2A/KLRC1/CD159a VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T15783-Ag | Rat | Rat NKG2A/KLRC1/CD159a VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T15783-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque NKG2A/KLRC1/CD159a VLP (virus-like particle) | HEK293 | Products Developing |
