Explore PAI-1/Serpin E1/SERPINE1 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. The protein also functions as a component of innate antiviral immunity. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. [provided by RefSeq, Aug 2020]
| Target ID |
GM-T15556
|
| Target Name |
PAI-1/Serpin E1/SERPINE1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
5054
|
| Gene ID |
100033931 (Equus caballus), 100127105 (Felis catus), 18787 (Mus musculus), 24617 (Rattus norvegicus)
281375 (Bos taurus), 403476 (Canis lupus familiaris), 5054 (Homo sapiens), 713883 (Macaca mulatta)
|
| Target Alternative Names |
Endothelial plasminogen activator inhibitor,PAI,PAI-1,PAI1,PAI1A,PLANH1,Pai1,Pai1aa,Planh,Planh1,Plasminogen activator inhibitor 1,RATPAI1A,SERPINE1,Serpin E1,Serpine1
|
| Uniprot Accession |
P22777,P20961,P13909,P05121
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Cytokine Target
|
| Disease |
cancer, Ovary Cancer, Malignant neoplasm of bladder
|
| Disease from KEGG |
HIF-1 signaling pathway, p53 signaling pathway, Cellular senescence, Hippo signaling pathway, Complement and coagulation cascades, AGE-RAGE signaling pathway in diabetic complications, Chagas disease
|
| Gene Ensembl |
ENSECAG00000019781, ENSMUSG00000037411, ENSCAFG00845000607, ENSG00000106366, ENSMMUG00000009926
|
Pre-made viral vector of PAI-1/Serpin E1/SERPINE1 cDNA Clones/ORF Plasmid
PAI-1/Serpin E1/SERPINE1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo5054 | Pre-made Human SERPINE1/PAI/PAI1 siRNA oligo Duplex | 5054 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo24617 | Pre-made Rat Serpine1/Pai1/PAI1A siRNA oligo Duplex | 24617 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo18787 | Pre-made Mouse Serpine1/PAI1/PAI-1 siRNA oligo Duplex | 18787 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo713883 | Pre-made Cynomolgus/Rhesus macaque SERPINE1 siRNA oligo Duplex | 713883 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100127105 | Pre-made Cat/Feline SERPINE1/PAI-1 siRNA oligo Duplex | 100127105 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403476 | Pre-made Dog/Canine SERPINE1/PAI-1 siRNA oligo Duplex | 403476 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281375 | Pre-made Bovines/Cattle SERPINE1/PAI1 siRNA oligo Duplex | 281375 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100033931 | Pre-made Equine/Horse SERPINE1/PAI-1 siRNA oligo Duplex | 100033931 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
PAI-1/Serpin E1/SERPINE1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T15556-Ab | Human | Anti-Human PAI-1/Serpin E1/SERPINE1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-rg-T15556-Ab | Rat | Anti-Rat PAI-1/Serpin E1/SERPINE1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-mg-T15556-Ab | Mouse | Anti-Mouse PAI-1/Serpin E1/SERPINE1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-T15556-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque PAI-1/Serpin E1/SERPINE1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-felg-T15556-Ab | Cat/Feline | Anti-Cat/Feline PAI-1/Serpin E1/SERPINE1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cang-T15556-Ab | Dog/Canine | Anti-Dog/Canine PAI-1/Serpin E1/SERPINE1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-T15556-Ab | Bovines/Cattle | Anti-Bovines/Cattle PAI-1/Serpin E1/SERPINE1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-equg-T15556-Ab | Equine/Horse | Anti-Equine/Horse PAI-1/Serpin E1/SERPINE1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
PAI-1/Serpin E1/SERPINE1 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T15556-Ag | Human | Human PAI-1/Serpin E1/SERPINE1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T15556-Ag | Rat | Rat PAI-1/Serpin E1/SERPINE1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T15556-Ag | Mouse | Mouse PAI-1/Serpin E1/SERPINE1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T15556-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque PAI-1/Serpin E1/SERPINE1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T15556-Ag | Cat/Feline | Cat/Feline PAI-1/Serpin E1/SERPINE1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T15556-Ag | Dog/Canine | Dog/Canine PAI-1/Serpin E1/SERPINE1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T15556-Ag | Bovines/Cattle | Bovines/Cattle PAI-1/Serpin E1/SERPINE1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T15556-Ag | Equine/Horse | Equine/Horse PAI-1/Serpin E1/SERPINE1 VLP (virus-like particle) | HEK293 | Products Developing |
