Explore FAK/PTK2 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017]
| Target ID |
GM-T15068
|
| Target Name |
FAK/PTK2
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
5747
|
| Gene ID |
100058245 (Equus caballus), 101095952 (Felis catus), 14083 (Mus musculus), 25614 (Rattus norvegicus)
475108 (Canis lupus familiaris), 506270 (Bos taurus), 5747 (Homo sapiens), 700634 (Macaca mulatta)
|
| Target Alternative Names |
FADK,FADK 1,FAK,FAK1,FRNK,Fadk,Focal adhesion kinase 1,Focal adhesion kinase-related nonkinase (FRNK),PPP1R71,PTK2,Protein phosphatase 1 regulatory subunit 71 (PPP1R71),Protein-tyrosine kinase 2,Ptk2,p125FAK,pp125FAK
|
| Uniprot Accession |
P34152,O35346,Q05397
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
Endocrine resistance, ErbB signaling pathway, Chemokine signaling pathway, PI3K-Akt signaling pathway, Axon guidance, Focal adhesion, Leukocyte transendothelial migration, Regulation of actin cytoskeleton, Growth hormone synthesis, secretion and action, Yersinia infection, Amoebiasis, Human cytomegalovirus infection, Human papillomavirus infection, Pathways in cancer, Proteoglycans in cancer, Small cell lung cancer, Lipid and atherosclerosis, Fluid shear stress and atherosclerosis
|
| Gene Ensembl |
ENSECAG00000014150, ENSMUSG00000022607, ENSCAFG00845012455, ENSBTAG00000009578, ENSG00000169398, ENSMMUG00000002336
|
| Target Classification |
Kinase, Tumor-associated antigen (TAA)
|
Pre-made viral vector of FAK/PTK2 cDNA Clones/ORF Plasmid
FAK/PTK2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo5747 | Pre-made Human PTK2/FAK/FADK siRNA oligo Duplex | 5747 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25614 | Pre-made Rat Ptk2/FAK/FRNK siRNA oligo Duplex | 25614 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo14083 | Pre-made Mouse Ptk2/FAK/FRNK siRNA oligo Duplex | 14083 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo700634 | Pre-made Cynomolgus/Rhesus macaque PTK2 siRNA oligo Duplex | 700634 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101095952 | Pre-made Cat/Feline PTK2 siRNA oligo Duplex | 101095952 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo475108 | Pre-made Dog/Canine PTK2 siRNA oligo Duplex | 475108 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo506270 | Pre-made Bovines/Cattle PTK2/FADK siRNA oligo Duplex | 506270 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100058245 | Pre-made Equine/Horse PTK2 siRNA oligo Duplex | 100058245 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
FAK/PTK2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T15068-Ab | Human | Anti-Human FAK/PTK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T15068-Ab | Rat | Anti-Rat FAK/PTK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T15068-Ab | Mouse | Anti-Mouse FAK/PTK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T15068-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque FAK/PTK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T15068-Ab | Cat/Feline | Anti-Cat/Feline FAK/PTK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T15068-Ab | Dog/Canine | Anti-Dog/Canine FAK/PTK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T15068-Ab | Bovines/Cattle | Anti-Bovines/Cattle FAK/PTK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T15068-Ab | Equine/Horse | Anti-Equine/Horse FAK/PTK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
FAK/PTK2 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T15068-Ag | Human | Human FAK/PTK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T15068-Ag | Rat | Rat FAK/PTK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T15068-Ag | Mouse | Mouse FAK/PTK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T15068-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque FAK/PTK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T15068-Ag | Cat/Feline | Cat/Feline FAK/PTK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T15068-Ag | Dog/Canine | Dog/Canine FAK/PTK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T15068-Ag | Bovines/Cattle | Bovines/Cattle FAK/PTK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T15068-Ag | Equine/Horse | Equine/Horse FAK/PTK2 recombinant protein | Mammalian cell | Detail |
