Explore Caspase 10/p12/CASP10 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]
Target ID |
GM-T14894
|
Target Name |
Caspase 10/p12/CASP10
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
843
|
Gene ID |
100068201 (Equus caballus), 101085995 (Felis catus), 488472 (Canis lupus familiaris), 701295 (Macaca mulatta) 843 (Homo sapiens)
|
Target Alternative Names |
CASP10,MCH4,ALPS2,FLICE2,FLICE-2
|
Uniprot Accession |
Q92851
|
Uniprot Entry Name |
|
Protein Sub-location |
Introcelluar Protein
|
Category |
Therapeutics Target
|
Disease |
cancer
|
Disease from KEGG |
Apoptosis, RIG-I-like receptor signaling pathway, TNF signaling pathway, Tuberculosis, Hepatitis B
|
Gene Ensembl |
ENSECAG00000024244, ENSCAFG00845029977, ENSMMUG00000031297, ENSG00000003400
|
Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of Caspase 10/p12/CASP10 cDNA Clones/ORF Plasmid
Caspase 10/p12/CASP10 siRNA/miRNA/oligo for RNA interfence (RNAi)
Cat No. | Product Name | GeneID | Species | Grade | Detail |
---|
pGMoligo843 | Pre-made Human CASP10/MCH4/ALPS2 siRNA oligo Duplex | 843 | Human | In-vitro grade; in-vivo grade | Detail |
pGMoligo701295 | Pre-made Cynomolgus/Rhesus macaque CASP10 siRNA oligo Duplex | 701295 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
pGMoligo101085995 | Pre-made Cat/Feline CASP10 siRNA oligo Duplex | 101085995 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
pGMoligo488472 | Pre-made Dog/Canine CASP10 siRNA oligo Duplex | 488472 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
pGMoligo100068201 | Pre-made Equine/Horse CASP10 siRNA oligo Duplex | 100068201 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
Caspase 10/p12/CASP10 antibody/GMab
Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
---|
GM-Tg-hg-T14894-Ab | Human | Anti-Human Caspase 10/p12/CASP10 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
GM-Tg-cynog-T14894-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque Caspase 10/p12/CASP10 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
GM-Tg-felg-T14894-Ab | Cat/Feline | Anti-Cat/Feline Caspase 10/p12/CASP10 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
GM-Tg-cang-T14894-Ab | Dog/Canine | Anti-Dog/Canine Caspase 10/p12/CASP10 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
GM-Tg-equg-T14894-Ab | Equine/Horse | Anti-Equine/Horse Caspase 10/p12/CASP10 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
Caspase 10/p12/CASP10 recombinant protein
Cat No. | Species | Antigen Name | Expression Platform | Detail |
---|
GM-Tg-hg-T14894-Ag | Human | Human Caspase 10/p12/CASP10 recombinant protein | Mammalian cell | Detail |
GM-Tg-cynog-T14894-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque Caspase 10/p12/CASP10 recombinant protein | Mammalian cell | Detail |
GM-Tg-felg-T14894-Ag | Cat/Feline | Cat/Feline Caspase 10/p12/CASP10 recombinant protein | Mammalian cell | Detail |
GM-Tg-cang-T14894-Ag | Dog/Canine | Dog/Canine Caspase 10/p12/CASP10 recombinant protein | Mammalian cell | Detail |
GM-Tg-equg-T14894-Ag | Equine/Horse | Equine/Horse Caspase 10/p12/CASP10 recombinant protein | Mammalian cell | Detail |