Recombinant multi-species Caspase 10/p12/CASP10 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Caspase 10/p12/CASP10 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]
The Alternative Names of target: Caspase 10, p12, CASP10,Caspase-10,CASP-10,Apoptotic protease Mch-4, FAS-associated death domain protein interleukin-1B-converting enzyme 2 (FLICE2), ICE-like apoptotic protease 4,MCH4,ALPS2,FLICE2,FLICE-2

Target products collectionGo to Caspase 10/p12/CASP10 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T14894-Ab-1/ GM-Tg-hg-T14894-Ab-2 Human Caspase 10/p12/CASP10 protein Human
GM-Tg-rg-T14894-Ab-1/ GM-Tg-rg-T14894-Ab-2 Rat Caspase 10/p12/CASP10 protein Rat
GM-Tg-mg-T14894-Ab-1/ GM-Tg-mg-T14894-Ab-2 Mouse Caspase 10/p12/CASP10 protein Mouse
GM-Tg-cynog-T14894-Ab-1/ GM-Tg-cynog-T14894-Ab-2 Cynomolgus/Rhesus macaque Caspase 10/p12/CASP10 monoclonal antibody Cynomolgus/ Rhesus macaque
GM-Tg-felg-T14894-Ab-1/ GM-Tg-felg-T14894-Ab-2 Feline Caspase 10/p12/CASP10 protein Feline
GM-Tg-cang-T14894-Ab-1/ GM-Tg-cang-T14894-Ab-2 Canine Caspase 10/p12/CASP10 protein Canine
GM-Tg-bovg-T14894-Ab-1/ GM-Tg-bovg-T14894-Ab-2 Bovine Caspase 10/p12/CASP10 protein Bovine
GM-Tg-equg-T14894-Ab-1/ GM-Tg-equg-T14894-Ab-2 Equine Caspase 10/p12/CASP10 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T14894-Ab-1/ GM-Tg-hg-T14894-Ab-2; GM-Tg-rg-T14894-Ab-1/ GM-Tg-rg-T14894-Ab-2;
GM-Tg-mg-T14894-Ab-1/ GM-Tg-mg-T14894-Ab-2; GM-Tg-cynog-T14894-Ab-1/ GM-Tg-cynog-T14894-Ab-2;
GM-Tg-felg-T14894-Ab-1/ GM-Tg-felg-T14894-Ab-2; GM-Tg-cang-T14894-Ab-1/ GM-Tg-cang-T14894-Ab-2;
GM-Tg-bovg-T14894-Ab-1/ GM-Tg-bovg-T14894-Ab-2; GM-Tg-equg-T14894-Ab-1/ GM-Tg-equg-T14894-Ab-2
Products Name Caspase 10/p12/CASP10 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name Caspase 10/p12/CASP10
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Caspase 10/p12/CASP10 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.