Explore GIVA cPLA2 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
| Target ID |
GM-T14834
|
| Target Name |
GIVA cPLA2
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
5321
|
| Gene ID |
100033889 (Equus caballus), 101082033 (Felis catus), 18783 (Mus musculus), 24653 (Rattus norvegicus)
480048 (Canis lupus familiaris), 525072 (Bos taurus), 5321 (Homo sapiens), 716635 (Macaca mulatta)
|
| Target Alternative Names |
PLA2G4A,Pla2g4a,PLA2,PLA2G1B,cPLA2,Pla2g4,cPLA2alpha,cPLA2-alpha,Pla2c,GURDP,PLA2G4
|
| Uniprot Accession |
O77793,P47713,P50393,A4IFJ5,P47712
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
Metabolic pathways, MAPK signaling pathway, Ras signaling pathway, Phospholipase D signaling pathway, Vascular smooth muscle contraction, Platelet activation, Fc epsilon RI signaling pathway, Glutamatergic synapse, Serotonergic synapse, Inflammatory mediator regulation of TRP channels, GnRH signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Choline metabolism in cancer, Glycerophospholipid metabolism, Ether lipid metabolism, Arachidonic acid metabolism, Linoleic acid metabolism
|
| Gene Ensembl |
ENSECAG00000024810, ENSMUSG00000056220, ENSCAFG00845005405, ENSBTAG00000013298, ENSG00000116711, ENSMMUG00000021423
|
| Target Classification |
Tumor-associated antigen (TAA)
|
GIVA cPLA2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo5321 | Pre-made Human PLA2G4A/GURDP/cPLA2 siRNA oligo Duplex | 5321 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo24653 | Pre-made Rat Pla2g4a/Pla2c/cPLA2 siRNA oligo Duplex | 24653 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo18783 | Pre-made Mouse Pla2g4a/cPLA2/Pla2g4 siRNA oligo Duplex | 18783 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo716635 | Pre-made Cynomolgus/Rhesus macaque PLA2G4A siRNA oligo Duplex | 716635 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101082033 | Pre-made Cat/Feline PLA2G4A siRNA oligo Duplex | 101082033 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo480048 | Pre-made Dog/Canine PLA2G4A siRNA oligo Duplex | 480048 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo525072 | Pre-made Bovines/Cattle PLA2G4A siRNA oligo Duplex | 525072 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100033889 | Pre-made Equine/Horse PLA2G4A/PLA2/PLA2G1B siRNA oligo Duplex | 100033889 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
GIVA cPLA2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T14834-Ab | Human | Anti-Human GIVA cPLA2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T14834-Ab | Rat | Anti-Rat GIVA cPLA2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T14834-Ab | Mouse | Anti-Mouse GIVA cPLA2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T14834-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque GIVA cPLA2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T14834-Ab | Cat/Feline | Anti-Cat/Feline GIVA cPLA2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T14834-Ab | Dog/Canine | Anti-Dog/Canine GIVA cPLA2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T14834-Ab | Bovines/Cattle | Anti-Bovines/Cattle GIVA cPLA2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T14834-Ab | Equine/Horse | Anti-Equine/Horse GIVA cPLA2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
GIVA cPLA2 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T14834-Ag | Human | Human GIVA cPLA2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T14834-Ag | Rat | Rat GIVA cPLA2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T14834-Ag | Mouse | Mouse GIVA cPLA2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T14834-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque GIVA cPLA2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T14834-Ag | Cat/Feline | Cat/Feline GIVA cPLA2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T14834-Ag | Dog/Canine | Dog/Canine GIVA cPLA2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T14834-Ag | Bovines/Cattle | Bovines/Cattle GIVA cPLA2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T14834-Ag | Equine/Horse | Equine/Horse GIVA cPLA2 recombinant protein | Mammalian cell | Detail |
