Explore APRIL/TNFSF13/CD256 gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Secreted Protein/Potential Cytokines.
The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]
| Target ID |
GM-T14676
|
| Target Name |
APRIL/TNFSF13/CD256
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
8741
|
| Gene ID |
100147233 (Equus caballus), 100328582 (Felis catus), 100551507 (Macaca mulatta), 100568281 (Canis lupus familiaris) 287437 (Rattus norvegicus), 538567 (Bos taurus), 69583 (Mus musculus), 8741 (Homo sapiens)
|
| Target Alternative Names |
2310026N09Rik,A proliferation-inducing ligand (APRIL),APRIL,April,CD256,TALL-2,TALL2,TNF- and APOL-related leukocyte expressed ligand 2 (TALL-2),TNF-related death ligand 1 (TRDL-1),TNFSF13,TNLG7B,TRDL-1,Tall2,Tnfsf13,Tnlg7b,Trdl1,Tumor necrosis factor ligand superfamily member 13,UNQ383/PRO715,ZTNF2
|
| Uniprot Accession |
Q9D777,O75888
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target, Immuno-oncology Target, INN Index, Cytokine Target
|
| Disease |
cancer, Lupus Glomerulonephritis
|
| Disease from KEGG |
Cytokine-cytokine receptor interaction, Intestinal immune network for IgA production, Rheumatoid arthritis
|
| Gene Ensembl |
ENSECAG00000034840, ENSMMUG00000006327, ENSCAFG00845023070, ENSBTAG00000000130, ENSMUSG00000089669, ENSG00000161955
|
| Target Classification |
Checkpoint-Immuno Oncology
|
Pre-made viral vector of APRIL/TNFSF13/CD256 cDNA Clones/ORF Plasmid
APRIL/TNFSF13/CD256 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo8741 | Pre-made Human TNFSF13/APRIL/CD256 siRNA oligo Duplex | 8741 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo287437 | Pre-made Rat Tnfsf13/April/Tnlg7b siRNA oligo Duplex | 287437 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo69583 | Pre-made Mouse Tnfsf13/April/Tall2 siRNA oligo Duplex | 69583 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100551507 | Pre-made Cynomolgus/Rhesus macaque TNFSF13 siRNA oligo Duplex | 100551507 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100328582 | Pre-made Cat/Feline TNFSF13 siRNA oligo Duplex | 100328582 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100568281 | Pre-made Dog/Canine TNFSF13/TNLG7B siRNA oligo Duplex | 100568281 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo538567 | Pre-made Bovines/Cattle TNFSF13/APRIL/TNLG7B siRNA oligo Duplex | 538567 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100147233 | Pre-made Equine/Horse TNFSF13/TNLG7B siRNA oligo Duplex | 100147233 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
APRIL/TNFSF13/CD256 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T14676-Ab | Human | Anti-Human APRIL/TNFSF13/CD256 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-rg-T14676-Ab | Rat | Anti-Rat APRIL/TNFSF13/CD256 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-mg-T14676-Ab | Mouse | Anti-Mouse APRIL/TNFSF13/CD256 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-T14676-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque APRIL/TNFSF13/CD256 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-felg-T14676-Ab | Cat/Feline | Anti-Cat/Feline APRIL/TNFSF13/CD256 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cang-T14676-Ab | Dog/Canine | Anti-Dog/Canine APRIL/TNFSF13/CD256 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-T14676-Ab | Bovines/Cattle | Anti-Bovines/Cattle APRIL/TNFSF13/CD256 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-equg-T14676-Ab | Equine/Horse | Anti-Equine/Horse APRIL/TNFSF13/CD256 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
APRIL/TNFSF13/CD256 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T14676-Ag | Human | Human APRIL/TNFSF13/CD256 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T14676-Ag | Rat | Rat APRIL/TNFSF13/CD256 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T14676-Ag | Mouse | Mouse APRIL/TNFSF13/CD256 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T14676-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque APRIL/TNFSF13/CD256 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T14676-Ag | Cat/Feline | Cat/Feline APRIL/TNFSF13/CD256 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T14676-Ag | Dog/Canine | Dog/Canine APRIL/TNFSF13/CD256 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T14676-Ag | Bovines/Cattle | Bovines/Cattle APRIL/TNFSF13/CD256 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T14676-Ag | Equine/Horse | Equine/Horse APRIL/TNFSF13/CD256 recombinant protein | Mammalian cell | Detail |