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Target
sublocation: Secreted Protein/Potential Cytokines.
Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T14558
|
| Target Name |
TPSAB1/Tryptase
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
7177
|
| Gene ID |
7177 (Homo sapiens)
|
| Target Alternative Names |
TPS1,TPS2,TPSAB1,TPSB1,TPSB2,Tryptase,Tryptase I,Tryptase alpha-1,Tryptase alpha/beta-1,Tryptase-1,Tryptase-2
|
| Uniprot Accession |
Q15661
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Influenza A
|
| Gene Ensembl |
ENSG00000172236
|
Pre-made viral vector of TPSAB1/Tryptase cDNA Clones/ORF Plasmid
TPSAB1/Tryptase siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo7177 | Pre-made Human TPSAB1/TPS1/TPS2 siRNA oligo Duplex | 7177 | Human | In-vitro grade; in-vivo grade | Detail |
TPSAB1/Tryptase antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T14558-Ab | Human | Anti-Human TPSAB1/Tryptase monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
TPSAB1/Tryptase recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T14558-Ag | Human | Human TPSAB1/Tryptase recombinant protein | Mammalian cell | Detail |
