Explore P27/KIP1/CDKN1B gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014]
| Target ID |
GM-T14006
|
| Target Name |
P27/KIP1/CDKN1B
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
1027
|
| Gene ID |
1027 (Homo sapiens), 111773925 (Equus caballus), 12576 (Mus musculus), 403429 (Canis lupus familiaris)
493958 (Felis catus), 512613 (Bos taurus), 697188 (Macaca mulatta), 83571 (Rattus norvegicus)
|
| Target Alternative Names |
CDKN1B,CDKN4,Cdki1b,Cdkn1b,Cyclin-dependent kinase inhibitor 1B,Cyclin-dependent kinase inhibitor p27,KIP1,Kip1,MEN1B,MEN4,P27,P27KIP1,p27,p27Kip1
|
| Uniprot Accession |
P46527,P46414,Q6SLL5,O19001
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
Endocrine resistance, ErbB signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, PI3K-Akt signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Cushing syndrome, Measles, Human papillomavirus infection, Epstein-Barr virus infection, Pathways in cancer, Prostate cancer, Chronic myeloid leukemia, Small cell lung cancer, Gastric cancer
|
| Gene Ensembl |
ENSG00000111276, ENSMUSG00000003031, ENSCAFG00845023770, ENSBTAG00000018254, ENSMMUG00000050457
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of P27/KIP1/CDKN1B cDNA Clones/ORF Plasmid
P27/KIP1/CDKN1B siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo1027 | Pre-made Human CDKN1B/KIP1/MEN4 siRNA oligo Duplex | 1027 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo83571 | Pre-made Rat Cdkn1b/p27/Kip1 siRNA oligo Duplex | 83571 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo12576 | Pre-made Mouse Cdkn1b/p27/Kip1 siRNA oligo Duplex | 12576 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo697188 | Pre-made Cynomolgus/Rhesus macaque CDKN1B siRNA oligo Duplex | 697188 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo493958 | Pre-made Cat/Feline CDKN1B/KIP1/p27Kip1 siRNA oligo Duplex | 493958 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403429 | Pre-made Dog/Canine CDKN1B/p27/Kip1 siRNA oligo Duplex | 403429 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo512613 | Pre-made Bovines/Cattle CDKN1B siRNA oligo Duplex | 512613 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo111773925 | Pre-made Equine/Horse CDKN1B siRNA oligo Duplex | 111773925 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
P27/KIP1/CDKN1B antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T14006-Ab | Human | Anti-Human P27/KIP1/CDKN1B monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T14006-Ab | Rat | Anti-Rat P27/KIP1/CDKN1B monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T14006-Ab | Mouse | Anti-Mouse P27/KIP1/CDKN1B monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T14006-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque P27/KIP1/CDKN1B monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T14006-Ab | Cat/Feline | Anti-Cat/Feline P27/KIP1/CDKN1B monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T14006-Ab | Dog/Canine | Anti-Dog/Canine P27/KIP1/CDKN1B monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T14006-Ab | Bovines/Cattle | Anti-Bovines/Cattle P27/KIP1/CDKN1B monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T14006-Ab | Equine/Horse | Anti-Equine/Horse P27/KIP1/CDKN1B monoclonal antibody | mab | Therapeutics Target antibody | Detail |
P27/KIP1/CDKN1B recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T14006-Ag | Human | Human P27/KIP1/CDKN1B recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T14006-Ag | Rat | Rat P27/KIP1/CDKN1B recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T14006-Ag | Mouse | Mouse P27/KIP1/CDKN1B recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T14006-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque P27/KIP1/CDKN1B recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T14006-Ag | Cat/Feline | Cat/Feline P27/KIP1/CDKN1B recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T14006-Ag | Dog/Canine | Dog/Canine P27/KIP1/CDKN1B recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T14006-Ag | Bovines/Cattle | Bovines/Cattle P27/KIP1/CDKN1B recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T14006-Ag | Equine/Horse | Equine/Horse P27/KIP1/CDKN1B recombinant protein | Mammalian cell | Detail |
