Explore CYP19A1 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Introcelluar Protein.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016]
| Target ID |
GM-T13260
|
| Target Name |
CYP19A1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
1588
|
| Gene ID |
100009712 (Equus caballus), 101094932 (Felis catus), 13075 (Mus musculus), 1588 (Homo sapiens)
25147 (Rattus norvegicus), 281740 (Bos taurus), 494003 (Canis lupus familiaris), 678697 (Macaca mulatta)
|
| Target Alternative Names |
ARO,ARO1,Ar,ArKO,Aromatase,CPV1,CYAR,CYP19,CYP19A1,CYP19P1,CYPXIX,Cyp19,Cyp19a,Cyp19a1,Cytochrome P-450AROM,Cytochrome P450 19A1,Estrogen synthase,Int-5,Int5,P-450AROM,P450AROM,p450arom
|
| Uniprot Accession |
O46512,P28649,P11511,P22443,P46194,Q5QQX7
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer, Breast cancer
|
| Disease from KEGG |
Metabolic pathways, Steroid hormone biosynthesis, Ovarian steroidogenesis
|
| Gene Ensembl |
ENSECAG00000020474, ENSMUSG00000032274, ENSG00000137869, ENSBTAG00000014890, ENSCAFG00845024965, ENSMMUG00000002553
|
Pre-made viral vector of CYP19A1 cDNA Clones/ORF Plasmid
CYP19A1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo1588 | Pre-made Human CYP19A1/ARO/ARO1 siRNA oligo Duplex | 1588 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25147 | Pre-made Rat Cyp19a1/Cyp19/Cyp19a siRNA oligo Duplex | 25147 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo13075 | Pre-made Mouse Cyp19a1/Ar/ArKO siRNA oligo Duplex | 13075 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo678697 | Pre-made Cynomolgus/Rhesus macaque CYP19A1 siRNA oligo Duplex | 678697 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101094932 | Pre-made Cat/Feline CYP19A1/P-450AROM siRNA oligo Duplex | 101094932 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo494003 | Pre-made Dog/Canine CYP19A1/CYP19 siRNA oligo Duplex | 494003 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281740 | Pre-made Bovines/Cattle CYP19A1/CYP19/CYP19P1 siRNA oligo Duplex | 281740 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100009712 | Pre-made Equine/Horse CYP19A1/CYPXIX/P450AROM siRNA oligo Duplex | 100009712 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
CYP19A1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T13260-Ab | Human | Anti-Human CYP19A1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T13260-Ab | Rat | Anti-Rat CYP19A1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T13260-Ab | Mouse | Anti-Mouse CYP19A1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T13260-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CYP19A1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T13260-Ab | Cat/Feline | Anti-Cat/Feline CYP19A1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T13260-Ab | Dog/Canine | Anti-Dog/Canine CYP19A1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T13260-Ab | Bovines/Cattle | Anti-Bovines/Cattle CYP19A1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T13260-Ab | Equine/Horse | Anti-Equine/Horse CYP19A1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
CYP19A1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T13260-Ag | Human | Human CYP19A1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T13260-Ag | Rat | Rat CYP19A1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T13260-Ag | Mouse | Mouse CYP19A1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T13260-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CYP19A1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T13260-Ag | Cat/Feline | Cat/Feline CYP19A1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T13260-Ag | Dog/Canine | Dog/Canine CYP19A1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T13260-Ag | Bovines/Cattle | Bovines/Cattle CYP19A1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T13260-Ag | Equine/Horse | Equine/Horse CYP19A1 recombinant protein | Mammalian cell | Detail |
