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Target
sublocation: Introcelluar Protein.
Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z. [provided by RefSeq, Oct 2008]
| Target ID |
GM-T12966
|
| Target Name |
TNNC1/TN-C
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
7134
|
| Gene ID |
100051811 (Equus caballus), 101082986 (Felis catus), 21924 (Mus musculus), 290561 (Rattus norvegicus)
476595 (Canis lupus familiaris), 509486 (Bos taurus), 697047 (Macaca mulatta), 7134 (Homo sapiens)
|
| Target Alternative Names |
CMD1Z,CMH13,TN-C,TNC,TNNC,TNNC1,TnC,Tncc,Tnnc1,Troponin C,cTnC,cTnI,slow skeletal and cardiac muscles,tncc
|
| Uniprot Accession |
P19123,P63315,P63316
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Calcium signaling pathway, Adrenergic signaling in cardiomyocytes, Hypertrophic cardiomyopathy, Dilated cardiomyopathy
|
| Gene Ensembl |
ENSMUSG00000091898, ENSCAFG00845030373, ENSBTAG00000045757, ENSMMUG00000005618, ENSG00000114854
|
Pre-made viral vector of TNNC1/TN-C cDNA Clones/ORF Plasmid
TNNC1/TN-C siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo7134 | Pre-made Human TNNC1/TNC/TN-C siRNA oligo Duplex | 7134 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo290561 | Pre-made Rat Tnnc1/Tncc siRNA oligo Duplex | 290561 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo21924 | Pre-made Mouse Tnnc1/TnC/cTnC siRNA oligo Duplex | 21924 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo697047 | Pre-made Cynomolgus/Rhesus macaque TNNC1 siRNA oligo Duplex | 697047 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101082986 | Pre-made Cat/Feline TNNC1 siRNA oligo Duplex | 101082986 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo476595 | Pre-made Dog/Canine TNNC1 siRNA oligo Duplex | 476595 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo509486 | Pre-made Bovines/Cattle TNNC1 siRNA oligo Duplex | 509486 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100051811 | Pre-made Equine/Horse TNNC1 siRNA oligo Duplex | 100051811 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
TNNC1/TN-C antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T12966-Ab | Human | Anti-Human TNNC1/TN-C monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T12966-Ab | Rat | Anti-Rat TNNC1/TN-C monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T12966-Ab | Mouse | Anti-Mouse TNNC1/TN-C monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T12966-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque TNNC1/TN-C monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T12966-Ab | Cat/Feline | Anti-Cat/Feline TNNC1/TN-C monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T12966-Ab | Dog/Canine | Anti-Dog/Canine TNNC1/TN-C monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T12966-Ab | Bovines/Cattle | Anti-Bovines/Cattle TNNC1/TN-C monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T12966-Ab | Equine/Horse | Anti-Equine/Horse TNNC1/TN-C monoclonal antibody | mab | Therapeutics Target antibody | Detail |
TNNC1/TN-C recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T12966-Ag | Human | Human TNNC1/TN-C recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T12966-Ag | Rat | Rat TNNC1/TN-C recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T12966-Ag | Mouse | Mouse TNNC1/TN-C recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T12966-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque TNNC1/TN-C recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T12966-Ag | Cat/Feline | Cat/Feline TNNC1/TN-C recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T12966-Ag | Dog/Canine | Dog/Canine TNNC1/TN-C recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T12966-Ag | Bovines/Cattle | Bovines/Cattle TNNC1/TN-C recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T12966-Ag | Equine/Horse | Equine/Horse TNNC1/TN-C recombinant protein | Mammalian cell | Detail |
