Explore CYP2B6 gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T11793
|
| Target Name |
CYP2B6
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
1555
|
| Gene ID |
105259649 (Felis catus), 1555 (Homo sapiens), 474177 (Canis lupus familiaris)
|
| Target Alternative Names |
CYP2B6,CPB6,EFVM,IIB1,P450,CYP2B,CYP2B7,CYP2B7P,CYPIIB6,CYP2B11,CYPIIB11
|
| Uniprot Accession |
P20813,P24460
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
Metabolic pathways, Chemical carcinogenesis - receptor activation, Lipid and atherosclerosis, Arachidonic acid metabolism, Retinol metabolism, Drug metabolism - cytochrome P450
|
| Gene Ensembl |
ENSG00000197408, ENSCAFG00845002728
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of CYP2B6 cDNA Clones/ORF Plasmid
CYP2B6 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo1555 | Pre-made Human CYP2B6/CPB6/EFVM siRNA oligo Duplex | 1555 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo105259649 | Pre-made Cat/Feline CYP2B6 siRNA oligo Duplex | 105259649 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo474177 | Pre-made Dog/Canine CYP2B6/CYP2B11/CYPIIB11 siRNA oligo Duplex | 474177 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
CYP2B6 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T11793-Ab | Human | Anti-Human CYP2B6 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T11793-Ab | Cat/Feline | Anti-Cat/Feline CYP2B6 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T11793-Ab | Dog/Canine | Anti-Dog/Canine CYP2B6 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
CYP2B6 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T11793-Ag | Human | Human CYP2B6 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T11793-Ag | Cat/Feline | Cat/Feline CYP2B6 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T11793-Ag | Dog/Canine | Dog/Canine CYP2B6 recombinant protein | Mammalian cell | Detail |
