AFP Target & Gene Products-cDNA ORF clones/siRNA/antibody/protein

Explore AFP gene products and cross-species research data at TarMart platform. Discover comprehensive biological information, expression tools, and therapeutic insights for Homo sapiens (human), Cynomolgus monkeys, rodents (mouse/rat), canines, felines, bovines, and equines. Your premier destination for multi-species gene research solutions
Target sublocation: Secreted Protein/Potential Cytokines.
This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatocarcinoma and with teratoma, and has prognostic value for managing advanced gastric cancer. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Oct 2019]

Target ID GM-T10828
Target Name AFP
Gene Group ldentifer
(Target Gene ID in Homo species)
174
Gene ID 100034185 (Equus caballus), 101082056 (Felis catus), 11576 (Mus musculus), 174 (Homo sapiens)
403551 (Canis lupus familiaris), 506011 (Bos taurus), 704786 (Macaca mulatta)
Target Alternative Names AFP,AFPD,Afp,Alpha-1-fetoprotein,Alpha-fetoglobulin,Alpha-fetoprotein,FETA,HPAFP
Uniprot Accession P49066,P02772,P02771,Q8MJU5,Q3SZ57
Protein Sub-location Secreted Protein/Potential Cytokines
Category Therapeutics Target, Diagnostics Biomarker, Immuno-oncology Target, INN Index
Disease cancer, Ovary Cancer, Hepatocellular carcinoma, malformations and congenital abnormalities, neural tube defects, Ovarian cancer, Pancreoblastoma, Teratoma, Teratoma: oral cavity, testicular germ cell tumors, Tumors: Desmoplastic small round cell tumor (DSRCT), Tumors: endodermal sinus tumor, Tumors: Epithelial liver tumors, Tumors: Intracranial germ cell, Germ cell tumors (GCT), Down's syndrome, Cancer: Germ cell tumors, Hepatic cancer, hepatocellular cancer, liver diseases
Disease from KEGG Hippo signaling pathway
Gene Ensembl ENSECAG00000023229, ENSMUSG00000054932, ENSG00000081051, ENSCAFG00845005947, ENSBTAG00000017131, ENSMMUG00000003830
Target Classification Checkpoint-Immuno Oncology


Pre-made viral vector of AFP cDNA Clones/ORF Plasmid

Cat No.Product NameNMIDGeneIDSpeciesTypeMarkerFusion TagPromoterDetail
pGMAP000189Human AFP/FETA Adenovirus plasmidBC027881174HumanAdenovirus plasmidGFP3xflag (C-Terminal)EF1Detail
vGMAP000189Human AFP/FETA Adenovirus particleBC027881174HumanAdenovirus particleGFP3xflag (C-Terminal)EF1Detail
pGMLV001570Mouse Afp Lentivirus plasmidNM_007423.411576MouseLentivirus plasmidZsGreen3xflag (C-Terminal)CMVDetail
vGMLV001570Mouse Afp Lentivirus particleNM_007423.411576MouseLentivirus particleZsGreen3xflag (C-Terminal)CMVDetail


AFP siRNA/miRNA/oligo for RNA interfence (RNAi)

Cat No.Product NameGeneIDSpeciesGradeDetail
pGMoligo174Pre-made Human AFP/AFPD/FETA siRNA oligo Duplex174HumanIn-vitro grade; in-vivo gradeDetail
pGMoligo11576Pre-made Mouse Afp siRNA oligo Duplex11576MouseIn-vitro grade; in-vivo gradeDetail
pGMoligo704786Pre-made Cynomolgus/Rhesus macaque AFP siRNA oligo Duplex704786Cynomolgus/Rhesus macaqueIn-vitro grade; in-vivo gradeDetail
pGMoligo101082056Pre-made Cat/Feline AFP siRNA oligo Duplex101082056Cat/FelineIn-vitro grade; in-vivo gradeDetail
pGMoligo403551Pre-made Dog/Canine AFP siRNA oligo Duplex403551Dog/CanineIn-vitro grade; in-vivo gradeDetail
pGMoligo506011Pre-made Bovines/Cattle AFP siRNA oligo Duplex506011Bovines/CattleIn-vitro grade; in-vivo gradeDetail
pGMoligo100034185Pre-made Equine/Horse AFP siRNA oligo Duplex100034185Equine/HorseIn-vitro grade; in-vivo gradeDetail


AFP antibody/GMab

Cat No.SpeciesAntibody NameFormatClassified by tagDetail
GM-Tg-hg-T10828-AbHumanAnti-Human AFP monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibodyDetail
GM-Tg-mg-T10828-AbMouseAnti-Mouse AFP monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibodyDetail
GM-Tg-cynog-T10828-AbCynomolgus/Rhesus macaqueAnti-Cynomolgus/Rhesus macaque AFP monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibodyDetail
GM-Tg-felg-T10828-AbCat/FelineAnti-Cat/Feline AFP monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibodyDetail
GM-Tg-cang-T10828-AbDog/CanineAnti-Dog/Canine AFP monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibodyDetail
GM-Tg-bovg-T10828-AbBovines/CattleAnti-Bovines/Cattle AFP monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibodyDetail
GM-Tg-equg-T10828-AbEquine/HorseAnti-Equine/Horse AFP monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibodyDetail


AFP recombinant protein

Cat No.SpeciesAntigen NameExpression PlatformDetail
GM-Tg-hg-T10828-AgHumanHuman AFP recombinant proteinMammalian cellDetail
GM-Tg-mg-T10828-AgMouseMouse AFP recombinant proteinMammalian cellDetail
GM-Tg-cynog-T10828-AgCynomolgus/Rhesus macaqueCynomolgus/Rhesus macaque AFP recombinant proteinMammalian cellDetail
GM-Tg-felg-T10828-AgCat/FelineCat/Feline AFP recombinant proteinMammalian cellDetail
GM-Tg-cang-T10828-AgDog/CanineDog/Canine AFP recombinant proteinMammalian cellDetail
GM-Tg-bovg-T10828-AgBovines/CattleBovines/Cattle AFP recombinant proteinMammalian cellDetail
GM-Tg-equg-T10828-AgEquine/HorseEquine/Horse AFP recombinant proteinMammalian cellDetail