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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatocarcinoma and with teratoma, and has prognostic value for managing advanced gastric cancer. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Oct 2019]
| Target ID |
GM-T10828
|
| Target Name |
AFP
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
174
|
| Gene ID |
100034185 (Equus caballus), 101082056 (Felis catus), 11576 (Mus musculus), 174 (Homo sapiens) 403551 (Canis lupus familiaris), 506011 (Bos taurus), 704786 (Macaca mulatta)
|
| Target Alternative Names |
AFP,AFPD,Afp,Alpha-1-fetoprotein,Alpha-fetoglobulin,Alpha-fetoprotein,FETA,HPAFP
|
| Uniprot Accession |
P49066,P02772,P02771,Q8MJU5,Q3SZ57
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target, Diagnostics Biomarker, Immuno-oncology Target, INN Index
|
| Disease |
cancer, Ovary Cancer, Hepatocellular carcinoma, malformations and congenital abnormalities, neural tube defects, Ovarian cancer, Pancreoblastoma, Teratoma, Teratoma: oral cavity, testicular germ cell tumors, Tumors: Desmoplastic small round cell tumor (DSRCT), Tumors: endodermal sinus tumor, Tumors: Epithelial liver tumors, Tumors: Intracranial germ cell, Germ cell tumors (GCT), Down's syndrome, Cancer: Germ cell tumors, Hepatic cancer, hepatocellular cancer, liver diseases
|
| Disease from KEGG |
Hippo signaling pathway
|
| Gene Ensembl |
ENSECAG00000023229, ENSMUSG00000054932, ENSG00000081051, ENSCAFG00845005947, ENSBTAG00000017131, ENSMMUG00000003830
|
| Target Classification |
Checkpoint-Immuno Oncology
|
Pre-made viral vector of AFP cDNA Clones/ORF Plasmid
AFP siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo174 | Pre-made Human AFP/AFPD/FETA siRNA oligo Duplex | 174 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo11576 | Pre-made Mouse Afp siRNA oligo Duplex | 11576 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo704786 | Pre-made Cynomolgus/Rhesus macaque AFP siRNA oligo Duplex | 704786 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101082056 | Pre-made Cat/Feline AFP siRNA oligo Duplex | 101082056 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403551 | Pre-made Dog/Canine AFP siRNA oligo Duplex | 403551 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo506011 | Pre-made Bovines/Cattle AFP siRNA oligo Duplex | 506011 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100034185 | Pre-made Equine/Horse AFP siRNA oligo Duplex | 100034185 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
AFP antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T10828-Ab | Human | Anti-Human AFP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody | Detail |
| GM-Tg-mg-T10828-Ab | Mouse | Anti-Mouse AFP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody | Detail |
| GM-Tg-cynog-T10828-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque AFP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody | Detail |
| GM-Tg-felg-T10828-Ab | Cat/Feline | Anti-Cat/Feline AFP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody | Detail |
| GM-Tg-cang-T10828-Ab | Dog/Canine | Anti-Dog/Canine AFP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody | Detail |
| GM-Tg-bovg-T10828-Ab | Bovines/Cattle | Anti-Bovines/Cattle AFP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody | Detail |
| GM-Tg-equg-T10828-Ab | Equine/Horse | Anti-Equine/Horse AFP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody | Detail |
AFP recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T10828-Ag | Human | Human AFP recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T10828-Ag | Mouse | Mouse AFP recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T10828-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque AFP recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T10828-Ag | Cat/Feline | Cat/Feline AFP recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T10828-Ag | Dog/Canine | Dog/Canine AFP recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T10828-Ag | Bovines/Cattle | Bovines/Cattle AFP recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T10828-Ag | Equine/Horse | Equine/Horse AFP recombinant protein | Mammalian cell | Detail |