Explore DKK2 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). [provided by RefSeq, Jul 2008]
| Target ID |
GM-T10125
|
| Target Name |
DKK2
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
27123
|
| Gene ID |
100064408 (Equus caballus), 101090100 (Felis catus), 27123 (Homo sapiens), 295445 (Rattus norvegicus) 478502 (Canis lupus familiaris), 541161 (Bos taurus), 56811 (Mus musculus), 694869 (Macaca mulatta)
|
| Target Alternative Names |
DKK-2,DKK2,Dickkopf-2,Dickkopf-related protein 2,Dkk-2,Dkk2,hDkk-2
|
| Uniprot Accession |
Q9UBU2,Q9QYZ8
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Wnt signaling pathway, Alzheimer disease
|
| Gene Ensembl |
ENSECAG00000032911, ENSG00000155011, ENSCAFG00845028785, ENSBTAG00000012969, ENSMUSG00000028031, ENSMMUG00000051654
|
Pre-made viral vector of DKK2 cDNA Clones/ORF Plasmid
DKK2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo27123 | Pre-made Human DKK2/DKK-2 siRNA oligo Duplex | 27123 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo295445 | Pre-made Rat Dkk2 siRNA oligo Duplex | 295445 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo56811 | Pre-made Mouse Dkk2 siRNA oligo Duplex | 56811 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo694869 | Pre-made Cynomolgus/Rhesus macaque DKK2 siRNA oligo Duplex | 694869 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101090100 | Pre-made Cat/Feline DKK2 siRNA oligo Duplex | 101090100 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo478502 | Pre-made Dog/Canine DKK2 siRNA oligo Duplex | 478502 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo541161 | Pre-made Bovines/Cattle DKK2 siRNA oligo Duplex | 541161 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100064408 | Pre-made Equine/Horse DKK2 siRNA oligo Duplex | 100064408 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
DKK2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T10125-Ab | Human | Anti-Human DKK2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T10125-Ab | Rat | Anti-Rat DKK2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T10125-Ab | Mouse | Anti-Mouse DKK2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T10125-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque DKK2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T10125-Ab | Cat/Feline | Anti-Cat/Feline DKK2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T10125-Ab | Dog/Canine | Anti-Dog/Canine DKK2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T10125-Ab | Bovines/Cattle | Anti-Bovines/Cattle DKK2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T10125-Ab | Equine/Horse | Anti-Equine/Horse DKK2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
DKK2 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T10125-Ag | Human | Human DKK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T10125-Ag | Rat | Rat DKK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T10125-Ag | Mouse | Mouse DKK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T10125-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque DKK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T10125-Ag | Cat/Feline | Cat/Feline DKK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T10125-Ag | Dog/Canine | Dog/Canine DKK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T10125-Ag | Bovines/Cattle | Bovines/Cattle DKK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T10125-Ag | Equine/Horse | Equine/Horse DKK2 recombinant protein | Mammalian cell | Detail |