Explore PrP/PRNP gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
| Target ID |
GM-T08722
|
| Target Name |
PrP/PRNP
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
5621
|
| Gene ID |
100065904 (Equus caballus), 101087310 (Felis catus), 19122 (Mus musculus), 24686 (Rattus norvegicus)
281427 (Bos taurus), 485783 (Canis lupus familiaris), 5621 (Homo sapiens), 717859 (Macaca mulatta)
|
| Target Alternative Names |
PRNP,Prnp,PRP,prmp,PrP,PrPC,Sinc,CD230,PrPSc,Prn-i,Prn-p,PrP<C>,prP27-30,prP33-35C,Prn,prn,AltPrP,CJD,GSS,ASCR,KURU,PRIP,PrPc,p27-30,PrP27-30,PrP33-35C
|
| Uniprot Accession |
O18754,P04925,P13852,F7VJQ2,P10279,O46501,F7VJQ1,P04156,P67997
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease |
|
| Disease from KEGG |
Ferroptosis
|
| Gene Ensembl |
ENSECAG00000029062, ENSMUSG00000079037, ENSBTAG00000063812, ENSCAFG00845013725, ENSG00000171867, ENSMMUG00000062847
|
| Target Classification |
|
Pre-made viral vector of PrP/PRNP cDNA Clones/ORF Plasmid
PrP/PRNP siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo5621 | Pre-made Human PRNP/CJD/GSS siRNA oligo Duplex | 5621 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo24686 | Pre-made Rat Prnp/PrP/Prn siRNA oligo Duplex | 24686 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo19122 | Pre-made Mouse Prnp/PrP/PrPC siRNA oligo Duplex | 19122 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo717859 | Pre-made Cynomolgus/Rhesus macaque PRNP siRNA oligo Duplex | 717859 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101087310 | Pre-made Cat/Feline PRNP/PRP siRNA oligo Duplex | 101087310 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo485783 | Pre-made Dog/Canine PRNP/PrP siRNA oligo Duplex | 485783 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281427 | Pre-made Bovines/Cattle PRNP/PrP/prn siRNA oligo Duplex | 281427 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100065904 | Pre-made Equine/Horse PRNP/PRP/prmp siRNA oligo Duplex | 100065904 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
PrP/PRNP antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T08722-Ab | Human | Anti-Human PrP/PRNP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T08722-Ab | Rat | Anti-Rat PrP/PRNP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T08722-Ab | Mouse | Anti-Mouse PrP/PRNP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T08722-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque PrP/PRNP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T08722-Ab | Cat/Feline | Anti-Cat/Feline PrP/PRNP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T08722-Ab | Dog/Canine | Anti-Dog/Canine PrP/PRNP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T08722-Ab | Bovines/Cattle | Anti-Bovines/Cattle PrP/PRNP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T08722-Ab | Equine/Horse | Anti-Equine/Horse PrP/PRNP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
PrP/PRNP VLP (virus-like particle)
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T08722-Ag | Human | Human PrP/PRNP VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T08722-Ag | Rat | Rat PrP/PRNP VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T08722-Ag | Mouse | Mouse PrP/PRNP VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T08722-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque PrP/PRNP VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T08722-Ag | Cat/Feline | Cat/Feline PrP/PRNP VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T08722-Ag | Dog/Canine | Dog/Canine PrP/PRNP VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T08722-Ag | Bovines/Cattle | Bovines/Cattle PrP/PRNP VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T08722-Ag | Equine/Horse | Equine/Horse PrP/PRNP VLP (virus-like particle) | HEK293 | Products Developing |
