Explore CD74 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
| Target ID |
GM-T08231
|
| Target Name |
CD74
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
972
|
| Gene ID |
100071644 (Equus caballus), 101085953 (Felis catus), 16149 (Mus musculus), 25599 (Rattus norvegicus)
479329 (Canis lupus familiaris), 613384 (Bos taurus), 710820 (Macaca mulatta), 972 (Homo sapiens)
|
| Target Alternative Names |
CD74,CLIP,Cd74,DHLAG,HLA class II histocompatibility antigen gamma chain,HLA-DR antigens-associated invariant chain,HLADG,II,INVG34,Ia antigen-associated invariant chain (Ii),Ia-GAMMA,Ii,p33
|
| Uniprot Accession |
P04441,P10247,P04233
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, INN Index
|
| Disease |
cancer
|
| Disease from KEGG |
Antigen processing and presentation, Tuberculosis
|
| Gene Ensembl |
ENSECAG00000008503, ENSMUSG00000024610, ENSCAFG00845006874, ENSBTAG00000015228, ENSMMUG00000009113, ENSG00000019582
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of CD74 cDNA Clones/ORF Plasmid
CD74 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo972 | Pre-made Human CD74/II/p33 siRNA oligo Duplex | 972 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25599 | Pre-made Rat Cd74/INVG34 siRNA oligo Duplex | 25599 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo16149 | Pre-made Mouse Cd74/Ii/CLIP siRNA oligo Duplex | 16149 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo710820 | Pre-made Cynomolgus/Rhesus macaque CD74 siRNA oligo Duplex | 710820 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101085953 | Pre-made Cat/Feline CD74 siRNA oligo Duplex | 101085953 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo479329 | Pre-made Dog/Canine CD74 siRNA oligo Duplex | 479329 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo613384 | Pre-made Bovines/Cattle CD74 siRNA oligo Duplex | 613384 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100071644 | Pre-made Equine/Horse CD74 siRNA oligo Duplex | 100071644 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
CD74 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T08231-Ab | Human | Anti-Human CD74 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T08231-Ab | Rat | Anti-Rat CD74 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T08231-Ab | Mouse | Anti-Mouse CD74 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T08231-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CD74 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T08231-Ab | Cat/Feline | Anti-Cat/Feline CD74 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T08231-Ab | Dog/Canine | Anti-Dog/Canine CD74 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T08231-Ab | Bovines/Cattle | Anti-Bovines/Cattle CD74 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T08231-Ab | Equine/Horse | Anti-Equine/Horse CD74 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
CD74 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T08231-Ag | Human | Human CD74 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T08231-Ag | Rat | Rat CD74 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T08231-Ag | Mouse | Mouse CD74 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T08231-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CD74 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T08231-Ag | Cat/Feline | Cat/Feline CD74 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T08231-Ag | Dog/Canine | Dog/Canine CD74 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T08231-Ag | Bovines/Cattle | Bovines/Cattle CD74 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T08231-Ag | Equine/Horse | Equine/Horse CD74 VLP (virus-like particle) | HEK293 | Products Developing |
