Explore LRRK2 gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T08123
|
| Target Name |
LRRK2
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
120892
|
| Gene ID |
100052935 (Equus caballus), 101096157 (Felis catus), 120892 (Homo sapiens), 300160 (Rattus norvegicus)
486608 (Canis lupus familiaris), 535652 (Bos taurus), 66725 (Mus musculus), 697930 (Macaca mulatta)
|
| Target Alternative Names |
4921513O20Rik,9330188B09Rik,AURA17,D630001M17Rik,DARDARIN,Dardarin,Gm927,LRRK2,Leucine-rich repeat serine/threonine-protein kinase 2,Lrrk2,PARK8,RIPK7,ROCO2,cI-46
|
| Uniprot Accession |
Q5S007,Q5S006
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
Parkinson's disease
|
| Gene Ensembl |
ENSECAG00000010288, ENSG00000188906, ENSCAFG00845030702, ENSBTAG00000016260, ENSMUSG00000036273, ENSMMUG00000015857
|
| Target Classification |
Kinase
|
LRRK2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo120892 | Pre-made Human LRRK2/PARK8/RIPK7 siRNA oligo Duplex | 120892 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo300160 | Pre-made Rat Lrrk2 siRNA oligo Duplex | 300160 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo66725 | Pre-made Mouse Lrrk2/Gm927/cI-46 siRNA oligo Duplex | 66725 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo697930 | Pre-made Cynomolgus/Rhesus macaque LRRK2 siRNA oligo Duplex | 697930 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101096157 | Pre-made Cat/Feline LRRK2 siRNA oligo Duplex | 101096157 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo486608 | Pre-made Dog/Canine LRRK2 siRNA oligo Duplex | 486608 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo535652 | Pre-made Bovines/Cattle LRRK2 siRNA oligo Duplex | 535652 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100052935 | Pre-made Equine/Horse LRRK2 siRNA oligo Duplex | 100052935 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
LRRK2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T08123-Ab | Human | Anti-Human LRRK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T08123-Ab | Rat | Anti-Rat LRRK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T08123-Ab | Mouse | Anti-Mouse LRRK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T08123-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque LRRK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T08123-Ab | Cat/Feline | Anti-Cat/Feline LRRK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T08123-Ab | Dog/Canine | Anti-Dog/Canine LRRK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T08123-Ab | Bovines/Cattle | Anti-Bovines/Cattle LRRK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T08123-Ab | Equine/Horse | Anti-Equine/Horse LRRK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
LRRK2 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T08123-Ag | Human | Human LRRK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T08123-Ag | Rat | Rat LRRK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T08123-Ag | Mouse | Mouse LRRK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T08123-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque LRRK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T08123-Ag | Cat/Feline | Cat/Feline LRRK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T08123-Ag | Dog/Canine | Dog/Canine LRRK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T08123-Ag | Bovines/Cattle | Bovines/Cattle LRRK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T08123-Ag | Equine/Horse | Equine/Horse LRRK2 recombinant protein | Mammalian cell | Detail |
