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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Introcelluar Protein.
The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T07766
|
| Target Name |
PAK2
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
5062
|
| Gene ID |
100060183 (Equus caballus), 101082845 (Felis catus), 224105 (Mus musculus), 29432 (Rattus norvegicus) 5062 (Homo sapiens), 513673 (Bos taurus), 612814 (Canis lupus familiaris), 710314 (Macaca mulatta)
|
| Target Alternative Names |
5330420P17Rik,A130002K10Rik,D16Ertd269e,Gamma-PAK,KNO2,PAK-2,PAK2,PAK65,PAKgamma,Pak2,S6/H4 kinase,Serine/threonine-protein kinase PAK 2,gamma-PAK,mKIAA4182,p21-activated kinase 2 (PAK-2),p58
|
| Uniprot Accession |
Q8CIN4,Q64303,Q13177
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, Axon guidance, Focal adhesion, T cell receptor signaling pathway, Regulation of actin cytoskeleton, Pathogenic Escherichia coli infection, Renal cell carcinoma
|
| Gene Ensembl |
ENSECAG00000020281, ENSMUSG00000022781, ENSG00000180370, ENSBTAG00000047856, ENSCAFG00845030194, ENSMMUG00000012033
|
| Target Classification |
Kinase
|
Pre-made viral vector of PAK2 cDNA Clones/ORF Plasmid
PAK2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo5062 | Pre-made Human PAK2/KNO2/PAK65 siRNA oligo Duplex | 5062 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo29432 | Pre-made Rat Pak2/PAK-2/gamma-PAK siRNA oligo Duplex | 29432 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo224105 | Pre-made Mouse Pak2/PAK-2/mKIAA4182 siRNA oligo Duplex | 224105 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo710314 | Pre-made Cynomolgus/Rhesus macaque PAK2 siRNA oligo Duplex | 710314 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101082845 | Pre-made Cat/Feline PAK2 siRNA oligo Duplex | 101082845 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo612814 | Pre-made Dog/Canine PAK2 siRNA oligo Duplex | 612814 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo513673 | Pre-made Bovines/Cattle PAK2 siRNA oligo Duplex | 513673 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100060183 | Pre-made Equine/Horse PAK2 siRNA oligo Duplex | 100060183 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
PAK2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T07766-Ab | Human | Anti-Human PAK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T07766-Ab | Rat | Anti-Rat PAK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T07766-Ab | Mouse | Anti-Mouse PAK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T07766-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque PAK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T07766-Ab | Cat/Feline | Anti-Cat/Feline PAK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T07766-Ab | Dog/Canine | Anti-Dog/Canine PAK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T07766-Ab | Bovines/Cattle | Anti-Bovines/Cattle PAK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T07766-Ab | Equine/Horse | Anti-Equine/Horse PAK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
PAK2 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T07766-Ag | Human | Human PAK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T07766-Ag | Rat | Rat PAK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T07766-Ag | Mouse | Mouse PAK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T07766-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque PAK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T07766-Ag | Cat/Feline | Cat/Feline PAK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T07766-Ag | Dog/Canine | Dog/Canine PAK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T07766-Ag | Bovines/Cattle | Bovines/Cattle PAK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T07766-Ag | Equine/Horse | Equine/Horse PAK2 recombinant protein | Mammalian cell | Detail |