Explore IRS2 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Introcelluar Protein.
This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T06128
|
| Target Name |
IRS2
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
8660
|
| Gene ID |
100146249 (Equus caballus), 100300012 (Bos taurus), 101095791 (Felis catus), 29376 (Rattus norvegicus)
384783 (Mus musculus), 485548 (Canis lupus familiaris), 698536 (Macaca mulatta), 8660 (Homo sapiens)
|
| Target Alternative Names |
4PS,IRS-2,IRS2,Insulin receptor substrate 2,Irs-2,Irs2
|
| Uniprot Accession |
P81122,Q9Y4H2
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
cGMP-PKG signaling pathway, FoxO signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Adipocytokine signaling pathway, Regulation of lipolysis in adipocytes, Type II diabetes mellitus, Insulin resistance, Growth hormone synthesis, secretion and action, Alzheimer disease
|
| Gene Ensembl |
ENSECAG00000003315, ENSBTAG00000012019, ENSMUSG00000038894, ENSCAFG00845018486, ENSMMUG00000021790, ENSG00000185950
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of IRS2 cDNA Clones/ORF Plasmid
IRS2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo8660 | Pre-made Human IRS2/IRS-2 siRNA oligo Duplex | 8660 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo29376 | Pre-made Rat Irs2/4PS/IRS-2 siRNA oligo Duplex | 29376 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo384783 | Pre-made Mouse Irs2/Irs-2 siRNA oligo Duplex | 384783 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo698536 | Pre-made Cynomolgus/Rhesus macaque IRS2 siRNA oligo Duplex | 698536 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101095791 | Pre-made Cat/Feline IRS2 siRNA oligo Duplex | 101095791 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo485548 | Pre-made Dog/Canine IRS2 siRNA oligo Duplex | 485548 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100300012 | Pre-made Bovines/Cattle IRS2 siRNA oligo Duplex | 100300012 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100146249 | Pre-made Equine/Horse IRS2 siRNA oligo Duplex | 100146249 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
IRS2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T06128-Ab | Human | Anti-Human IRS2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T06128-Ab | Rat | Anti-Rat IRS2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T06128-Ab | Mouse | Anti-Mouse IRS2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T06128-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque IRS2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T06128-Ab | Cat/Feline | Anti-Cat/Feline IRS2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T06128-Ab | Dog/Canine | Anti-Dog/Canine IRS2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T06128-Ab | Bovines/Cattle | Anti-Bovines/Cattle IRS2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T06128-Ab | Equine/Horse | Anti-Equine/Horse IRS2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
IRS2 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T06128-Ag | Human | Human IRS2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T06128-Ag | Rat | Rat IRS2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T06128-Ag | Mouse | Mouse IRS2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T06128-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque IRS2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T06128-Ag | Cat/Feline | Cat/Feline IRS2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T06128-Ag | Dog/Canine | Dog/Canine IRS2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T06128-Ag | Bovines/Cattle | Bovines/Cattle IRS2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T06128-Ag | Equine/Horse | Equine/Horse IRS2 recombinant protein | Mammalian cell | Detail |
