Explore HNF1A gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
The protein encoded by this gene is a transcription factor required for the expression of several liver-specific genes. The encoded protein functions as a homodimer and binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Defects in this gene are a cause of maturity onset diabetes of the young type 3 (MODY3) and also can result in the appearance of hepatic adenomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
| Target ID |
GM-T03556
|
| Target Name |
HNF1A
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
6927
|
| Gene ID |
100049993 (Equus caballus), 101098407 (Felis catus), 107001057 (Macaca mulatta), 21405 (Mus musculus)
24817 (Rattus norvegicus), 486303 (Canis lupus familiaris), 503578 (Bos taurus), 6927 (Homo sapiens)
|
| Target Alternative Names |
HNF-1-alpha,HNF-1A,HNF-1a,HNF1,HNF1-alpha,HNF1A,HNF1[a],HNF1alpha,HNF4A,Hepatocyte nuclear factor 1-alpha,Hnf-1,Hnf1a,Hnf1alpha,IDDM20,LF-B1,LFB1,Lfb1,Liver-specific transcription factor LF-B1 (LFB1),MODY3,TCF-1,TCF1,Tcf-1,Tcf1,Transcription factor 1 (TCF-1)
|
| Uniprot Accession |
P22361,P15257,P20823
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Gene Ensembl |
ENSECAG00000019954, ENSMMUG00000006435, ENSMUSG00000029556, ENSCAFG00845030116, ENSBTAG00000021795, ENSG00000135100
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of HNF1A cDNA Clones/ORF Plasmid
HNF1A siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo6927 | Pre-made Human HNF1A/HNF1/LFB1 siRNA oligo Duplex | 6927 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo24817 | Pre-made Rat Hnf1a/HNF1/Lfb1 siRNA oligo Duplex | 24817 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo21405 | Pre-made Mouse Hnf1a/HNF1/LFB1 siRNA oligo Duplex | 21405 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo107001057 | Pre-made Cynomolgus/Rhesus macaque HNF1A siRNA oligo Duplex | 107001057 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101098407 | Pre-made Cat/Feline HNF1A siRNA oligo Duplex | 101098407 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo486303 | Pre-made Dog/Canine HNF1A/HNF1/TCF1 siRNA oligo Duplex | 486303 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo503578 | Pre-made Bovines/Cattle HNF1A/HNF-1a siRNA oligo Duplex | 503578 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100049993 | Pre-made Equine/Horse HNF1A siRNA oligo Duplex | 100049993 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
HNF1A antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T03556-Ab | Human | Anti-Human HNF1A monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T03556-Ab | Rat | Anti-Rat HNF1A monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T03556-Ab | Mouse | Anti-Mouse HNF1A monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T03556-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque HNF1A monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T03556-Ab | Cat/Feline | Anti-Cat/Feline HNF1A monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T03556-Ab | Dog/Canine | Anti-Dog/Canine HNF1A monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T03556-Ab | Bovines/Cattle | Anti-Bovines/Cattle HNF1A monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T03556-Ab | Equine/Horse | Anti-Equine/Horse HNF1A monoclonal antibody | mab | Therapeutics Target antibody | Detail |
HNF1A recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T03556-Ag | Human | Human HNF1A recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T03556-Ag | Rat | Rat HNF1A recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T03556-Ag | Mouse | Mouse HNF1A recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T03556-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque HNF1A recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T03556-Ag | Cat/Feline | Cat/Feline HNF1A recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T03556-Ag | Dog/Canine | Dog/Canine HNF1A recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T03556-Ag | Bovines/Cattle | Bovines/Cattle HNF1A recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T03556-Ag | Equine/Horse | Equine/Horse HNF1A recombinant protein | Mammalian cell | Detail |
