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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease degrades soluble and insoluble elastin. This gene may play a role in aneurysm formation and mutations in this gene are associated with lung function and chronic obstructive pulmonary disease (COPD). This gene is part of a cluster of MMP genes on chromosome 11. [provided by RefSeq, Jan 2016]
| Target ID |
GM-T03500
|
| Target Name |
MMP12/MMP-12
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
4321
|
| Gene ID |
100069047 (Equus caballus), 101084472 (Felis catus), 117033 (Rattus norvegicus), 17381 (Mus musculus) 4321 (Homo sapiens), 526981 (Bos taurus), 611789 (Canis lupus familiaris), 703867 (Macaca mulatta)
|
| Target Alternative Names |
HME,ME,MME,MMP-12,MMP12,Macrophage elastase (ME,Macrophage metalloelastase,Matrix metalloproteinase-12 (MMP-12),Mme,Mmel,Mmp12,hME)
|
| Uniprot Accession |
Q63341,P34960,P39900
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Gene Ensembl |
ENSECAG00000056462, ENSMUSG00000049723, ENSG00000262406, ENSBTAG00000053542, ENSCAFG00845000798, ENSMMUG00000004250
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of MMP12/MMP-12 cDNA Clones/ORF Plasmid
MMP12/MMP-12 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo4321 | Pre-made Human MMP12/ME/HME siRNA oligo Duplex | 4321 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo117033 | Pre-made Rat Mmp12/Mme siRNA oligo Duplex | 117033 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo17381 | Pre-made Mouse Mmp12/MME/Mmel siRNA oligo Duplex | 17381 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo703867 | Pre-made Cynomolgus/Rhesus macaque MMP12 siRNA oligo Duplex | 703867 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101084472 | Pre-made Cat/Feline MMP12 siRNA oligo Duplex | 101084472 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo611789 | Pre-made Dog/Canine MMP12 siRNA oligo Duplex | 611789 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo526981 | Pre-made Bovines/Cattle MMP12 siRNA oligo Duplex | 526981 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100069047 | Pre-made Equine/Horse MMP12 siRNA oligo Duplex | 100069047 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
MMP12/MMP-12 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T03500-Ab | Human | Anti-Human MMP12/MMP-12 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T03500-Ab | Rat | Anti-Rat MMP12/MMP-12 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T03500-Ab | Mouse | Anti-Mouse MMP12/MMP-12 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T03500-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque MMP12/MMP-12 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T03500-Ab | Cat/Feline | Anti-Cat/Feline MMP12/MMP-12 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T03500-Ab | Dog/Canine | Anti-Dog/Canine MMP12/MMP-12 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T03500-Ab | Bovines/Cattle | Anti-Bovines/Cattle MMP12/MMP-12 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T03500-Ab | Equine/Horse | Anti-Equine/Horse MMP12/MMP-12 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
MMP12/MMP-12 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T03500-Ag | Human | Human MMP12/MMP-12 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T03500-Ag | Rat | Rat MMP12/MMP-12 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T03500-Ag | Mouse | Mouse MMP12/MMP-12 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T03500-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque MMP12/MMP-12 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T03500-Ag | Cat/Feline | Cat/Feline MMP12/MMP-12 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T03500-Ag | Dog/Canine | Dog/Canine MMP12/MMP-12 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T03500-Ag | Bovines/Cattle | Bovines/Cattle MMP12/MMP-12 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T03500-Ag | Equine/Horse | Equine/Horse MMP12/MMP-12 recombinant protein | Mammalian cell | Detail |