Explore PKC Epsilon/PRKCE gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T00895
|
| Target Name |
PKC Epsilon/PRKCE
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
5581
|
| Gene ID |
100053394 (Equus caballus), 101100958 (Felis catus), 18754 (Mus musculus), 29340 (Rattus norvegicus) 507041 (Bos taurus), 5581 (Homo sapiens), 609934 (Canis lupus familiaris), 714533 (Macaca mulatta)
|
| Target Alternative Names |
5830406C15Rik,PKC Epsilon,PKCE,PKC[e],PKCepsilon,PRKCE,Pkce,Prkce,Protein kinase C epsilon type,nPKC-epsilon
|
| Uniprot Accession |
P16054,P09216,Q02156
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
cGMP-PKG signaling pathway, Sphingolipid signaling pathway, Vascular smooth muscle contraction, Tight junction, Inflammatory mediator regulation of TRP channels, Aldosterone synthesis and secretion, Type II diabetes mellitus, Insulin resistance, AGE-RAGE signaling pathway in diabetic complications
|
| Gene Ensembl |
ENSMUSG00000045038, ENSBTAG00000020614, ENSG00000171132, ENSCAFG00845027571, ENSMMUG00000014425
|
| Target Classification |
Kinase
|
Pre-made viral vector of PKC Epsilon/PRKCE cDNA Clones/ORF Plasmid
PKC Epsilon/PRKCE siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo5581 | Pre-made Human PRKCE/PKCE/nPKC-epsilon siRNA oligo Duplex | 5581 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo29340 | Pre-made Rat Prkce/Pkce siRNA oligo Duplex | 29340 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo18754 | Pre-made Mouse Prkce/Pkce/PKC[e] siRNA oligo Duplex | 18754 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo714533 | Pre-made Cynomolgus/Rhesus macaque PRKCE siRNA oligo Duplex | 714533 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101100958 | Pre-made Cat/Feline PRKCE siRNA oligo Duplex | 101100958 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo609934 | Pre-made Dog/Canine PRKCE siRNA oligo Duplex | 609934 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo507041 | Pre-made Bovines/Cattle PRKCE siRNA oligo Duplex | 507041 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100053394 | Pre-made Equine/Horse PRKCE siRNA oligo Duplex | 100053394 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
PKC Epsilon/PRKCE antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T00895-Ab | Human | Anti-Human PKC Epsilon/PRKCE monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T00895-Ab | Rat | Anti-Rat PKC Epsilon/PRKCE monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T00895-Ab | Mouse | Anti-Mouse PKC Epsilon/PRKCE monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T00895-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque PKC Epsilon/PRKCE monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T00895-Ab | Cat/Feline | Anti-Cat/Feline PKC Epsilon/PRKCE monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T00895-Ab | Dog/Canine | Anti-Dog/Canine PKC Epsilon/PRKCE monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T00895-Ab | Bovines/Cattle | Anti-Bovines/Cattle PKC Epsilon/PRKCE monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T00895-Ab | Equine/Horse | Anti-Equine/Horse PKC Epsilon/PRKCE monoclonal antibody | mab | Therapeutics Target antibody | Detail |
PKC Epsilon/PRKCE recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T00895-Ag | Human | Human PKC Epsilon/PRKCE recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T00895-Ag | Rat | Rat PKC Epsilon/PRKCE recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T00895-Ag | Mouse | Mouse PKC Epsilon/PRKCE recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T00895-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque PKC Epsilon/PRKCE recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T00895-Ag | Cat/Feline | Cat/Feline PKC Epsilon/PRKCE recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T00895-Ag | Dog/Canine | Dog/Canine PKC Epsilon/PRKCE recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T00895-Ag | Bovines/Cattle | Bovines/Cattle PKC Epsilon/PRKCE recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T00895-Ag | Equine/Horse | Equine/Horse PKC Epsilon/PRKCE recombinant protein | Mammalian cell | Detail |