JNK/MAPK10/JNK3 Target & Gene Products-cDNA ORF clones/siRNA/antibody/protein
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Introcelluar Protein.
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system, and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
| Target ID | GM-T00663 |
| Target Name | JNK/MAPK10/JNK3 |
|
Gene Group ldentifer （Target Gene ID in Homo species) |
5602 |
| Gene ID |
100052608 (Equus caballus), 101101463 (Felis catus), 25272 (Rattus norvegicus), 26414 (Mus musculus) 478464 (Canis lupus familiaris), 537631 (Bos taurus), 5602 (Homo sapiens), 699736 (Macaca mulatta) |
| Target Alternative Names | C230008H04Rik,JNK,JNK3,JNK3A,JNK3B1,JNK3B2,Jnk3,MAP kinase 10,MAP kinase p49 3F12,MAPK 10,MAPK10,Mapk10,Mitogen-activated protein kinase 10,PRKM10,SAPK(beta),SAPK1b,SAPKC,SAPb,Serk2,Stress-activated protein kinase 1b (SAPK1b),Stress-activated protein kinase JNK3,c-Jun N-terminal kinase 3,p493F12,p54bSAPK |
| Uniprot Accession | P49187,Q61831,P53779 |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease from KEGG | Endocrine resistance, MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, cAMP signaling pathway, FoxO signaling pathway, Sphingolipid signaling pathway, Protein processing in endoplasmic reticulum, Apoptosis, Apoptosis - multiple species, Wnt signaling pathway, Osteoclast differentiation, Focal adhesion, Tight junction, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, C-type lectin receptor signaling pathway, IL-17 signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, TNF signaling pathway, Neurotrophin signaling pathway, Inflammatory mediator regulation of TRP channels, GnRH signaling pathway, Prolactin signaling pathway, Adipocytokine signaling pathway, Relaxin signaling pathway, Type II diabetes mellitus, Insulin resistance, AGE-RAGE signaling pathway in diabetic complications, Growth hormone synthesis, secretion and action, Alcoholic liver disease, Alzheimer disease, Epithelial cell signaling in Helicobacter pylori infection, Pathogenic Escherichia coli infection, Pertussis, Yersinia infection, Chagas disease, Toxoplasmosis, Tuberculosis, Hepatitis B, Measles, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Epstein-Barr virus infection, Pathways in cancer, Colorectal cancer, Pancreatic cancer, Choline metabolism in cancer, Lipid and atherosclerosis, Fluid shear stress and atherosclerosis |
| Gene Ensembl | ENSECAG00000017280, ENSMUSG00000046709, ENSCAFG00845023201, ENSBTAG00000020048, ENSG00000109339, ENSMMUG00000008342 |
| Target Classification | Kinase |
Pre-made viral vector of JNK/MAPK10/JNK3 cDNA Clones/ORF Plasmid
| Cat No. | Product Name | NMID | GeneID | Species | Type | Marker | Fusion Tag | Promoter | Detail |
|---|---|---|---|---|---|---|---|---|---|
| pGMLPm002520 | Mouse Mapk10/C230008H04Rik/JNK3 Lentivirus plasmid | NM_001310683.1 | 26414 | Mouse | Lentivirus plasmid | ZsGreen | 3xflag (C-Terminal) | CMV | Detail |
| vGMLPm002520 | Mouse Mapk10/C230008H04Rik/JNK3 Lentivirus particle | NM_001310683.1 | 26414 | Mouse | Lentivirus particle | ZsGreen | 3xflag (C-Terminal) | CMV | Detail |
JNK/MAPK10/JNK3 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|---|---|---|---|---|
| pGMoligo5602 | Pre-made Human MAPK10/JNK3/JNK3A siRNA oligo Duplex | 5602 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25272 | Pre-made Rat Mapk10/Jnk3/SAPb siRNA oligo Duplex | 25272 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo26414 | Pre-made Mouse Mapk10/JNK3/Serk2 siRNA oligo Duplex | 26414 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo699736 | Pre-made Cynomolgus/Rhesus macaque MAPK10 siRNA oligo Duplex | 699736 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101101463 | Pre-made Cat/Feline MAPK10 siRNA oligo Duplex | 101101463 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo478464 | Pre-made Dog/Canine MAPK10 siRNA oligo Duplex | 478464 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo537631 | Pre-made Bovines/Cattle MAPK10 siRNA oligo Duplex | 537631 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100052608 | Pre-made Equine/Horse MAPK10 siRNA oligo Duplex | 100052608 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
JNK/MAPK10/JNK3 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|---|---|---|---|---|
| GM-Tg-hg-T00663-Ab | Human | Anti-Human JNK/MAPK10/JNK3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T00663-Ab | Rat | Anti-Rat JNK/MAPK10/JNK3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T00663-Ab | Mouse | Anti-Mouse JNK/MAPK10/JNK3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T00663-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque JNK/MAPK10/JNK3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T00663-Ab | Cat/Feline | Anti-Cat/Feline JNK/MAPK10/JNK3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T00663-Ab | Dog/Canine | Anti-Dog/Canine JNK/MAPK10/JNK3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T00663-Ab | Bovines/Cattle | Anti-Bovines/Cattle JNK/MAPK10/JNK3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T00663-Ab | Equine/Horse | Anti-Equine/Horse JNK/MAPK10/JNK3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
JNK/MAPK10/JNK3 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|---|---|---|---|
| GM-Tg-hg-T00663-Ag | Human | Human JNK/MAPK10/JNK3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T00663-Ag | Rat | Rat JNK/MAPK10/JNK3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T00663-Ag | Mouse | Mouse JNK/MAPK10/JNK3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T00663-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque JNK/MAPK10/JNK3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T00663-Ag | Cat/Feline | Cat/Feline JNK/MAPK10/JNK3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T00663-Ag | Dog/Canine | Dog/Canine JNK/MAPK10/JNK3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T00663-Ag | Bovines/Cattle | Bovines/Cattle JNK/MAPK10/JNK3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T00663-Ag | Equine/Horse | Equine/Horse JNK/MAPK10/JNK3 recombinant protein | Mammalian cell | Detail |