Explore PDI/P4HB gene products and cross-species
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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq, Jul 2008]
| Target ID |
GM-SE1636
|
| Target Name |
PDI/P4HB
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
5034
|
| Gene ID |
100055188 (Equus caballus), 101099917 (Felis catus), 18453 (Mus musculus), 25506 (Rattus norvegicus) 281373 (Bos taurus), 483369 (Canis lupus familiaris), 5034 (Homo sapiens), 714702 (Macaca mulatta)
|
| Target Alternative Names |
CLCRP1,Cellular thyroid hormone-binding protein,DSI,ERBA2L,ERp59,GIT,P4HB,P4Hbeta,P4hb,PDI,PDIA1,PDIR,PHDB,PO4DB,PO4HB,PROHB,Pdia1,Prolyl 4-hydroxylase subunit beta,Protein disulfide-isomerase,Thbp,p55
|
| Uniprot Accession |
P09103,P04785,P05307,P07237
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Disease |
Contrast - Induced Nephropathy
|
| Disease from KEGG |
Protein processing in endoplasmic reticulum
|
| Gene Ensembl |
ENSECAG00000009583, ENSMUSG00000025130, ENSBTAG00000006045, ENSCAFG00845009297, ENSG00000185624, ENSMMUG00000009242
|
Pre-made viral vector of PDI/P4HB cDNA Clones/ORF Plasmid
PDI/P4HB siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo5034 | Pre-made Human P4HB/DSI/GIT siRNA oligo Duplex | 5034 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25506 | Pre-made Rat P4hb/PDI/PDIR siRNA oligo Duplex | 25506 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo18453 | Pre-made Mouse P4hb/PDI/Thbp siRNA oligo Duplex | 18453 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo714702 | Pre-made Cynomolgus/Rhesus macaque P4HB siRNA oligo Duplex | 714702 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101099917 | Pre-made Cat/Feline P4HB siRNA oligo Duplex | 101099917 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo483369 | Pre-made Dog/Canine P4HB siRNA oligo Duplex | 483369 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281373 | Pre-made Bovines/Cattle P4HB/PDI siRNA oligo Duplex | 281373 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100055188 | Pre-made Equine/Horse P4HB siRNA oligo Duplex | 100055188 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
PDI/P4HB antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-SE1636-Ab | Human | Anti-Human PDI/P4HB monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-rg-SE1636-Ab | Rat | Anti-Rat PDI/P4HB monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-mg-SE1636-Ab | Mouse | Anti-Mouse PDI/P4HB monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cynog-SE1636-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque PDI/P4HB monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-felg-SE1636-Ab | Cat/Feline | Anti-Cat/Feline PDI/P4HB monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cang-SE1636-Ab | Dog/Canine | Anti-Dog/Canine PDI/P4HB monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-bovg-SE1636-Ab | Bovines/Cattle | Anti-Bovines/Cattle PDI/P4HB monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-equg-SE1636-Ab | Equine/Horse | Anti-Equine/Horse PDI/P4HB monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
PDI/P4HB recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-SE1636-Ag | Human | Human PDI/P4HB recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-SE1636-Ag | Rat | Rat PDI/P4HB recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-SE1636-Ag | Mouse | Mouse PDI/P4HB recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-SE1636-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque PDI/P4HB recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-SE1636-Ag | Cat/Feline | Cat/Feline PDI/P4HB recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-SE1636-Ag | Dog/Canine | Dog/Canine PDI/P4HB recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-SE1636-Ag | Bovines/Cattle | Bovines/Cattle PDI/P4HB recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-SE1636-Ag | Equine/Horse | Equine/Horse PDI/P4HB recombinant protein | Mammalian cell | Detail |