Explore MSH3 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Secreted Protein/Potential Cytokines.
The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer. [provided by RefSeq, Mar 2011]
| Target ID |
GM-SE1464
|
| Target Name |
MSH3
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
4437
|
| Gene ID |
100073255 (Equus caballus), 101090919 (Felis catus), 17686 (Mus musculus), 4437 (Homo sapiens)
479164 (Canis lupus familiaris), 499505 (Rattus norvegicus), 616744 (Bos taurus), 711187 (Macaca mulatta)
|
| Target Alternative Names |
D13Em1,DNA mismatch repair protein Msh3,DUP,Divergent upstream protein (DUP),FAP4,MRP1,MSH3,Mismatch repair protein 1 (MRP1),Msh3,REP-1,Rep-3,Rep3,hMSH3
|
| Uniprot Accession |
P13705,P20585
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
|
| Disease |
cancer
|
| Disease from KEGG |
Pathways in cancer, Colorectal cancer
|
| Gene Ensembl |
ENSECAG00000009962, ENSMUSG00000014850, ENSG00000113318, ENSCAFG00845022317, ENSBTAG00000007684, ENSMMUG00000018284
|
| Target Classification |
Tumor-associated antigen (TAA)
|
MSH3 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo4437 | Pre-made Human MSH3/DUP/FAP4 siRNA oligo Duplex | 4437 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo499505 | Pre-made Rat Msh3 siRNA oligo Duplex | 499505 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo17686 | Pre-made Mouse Msh3/Rep3/REP-1 siRNA oligo Duplex | 17686 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo711187 | Pre-made Cynomolgus/Rhesus macaque MSH3 siRNA oligo Duplex | 711187 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101090919 | Pre-made Cat/Feline MSH3 siRNA oligo Duplex | 101090919 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo479164 | Pre-made Dog/Canine MSH3 siRNA oligo Duplex | 479164 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo616744 | Pre-made Bovines/Cattle MSH3 siRNA oligo Duplex | 616744 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100073255 | Pre-made Equine/Horse MSH3 siRNA oligo Duplex | 100073255 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
MSH3 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-SE1464-Ab | Human | Anti-Human MSH3 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-rg-SE1464-Ab | Rat | Anti-Rat MSH3 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-mg-SE1464-Ab | Mouse | Anti-Mouse MSH3 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cynog-SE1464-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque MSH3 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-felg-SE1464-Ab | Cat/Feline | Anti-Cat/Feline MSH3 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cang-SE1464-Ab | Dog/Canine | Anti-Dog/Canine MSH3 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-bovg-SE1464-Ab | Bovines/Cattle | Anti-Bovines/Cattle MSH3 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-equg-SE1464-Ab | Equine/Horse | Anti-Equine/Horse MSH3 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
MSH3 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-SE1464-Ag | Human | Human MSH3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-SE1464-Ag | Rat | Rat MSH3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-SE1464-Ag | Mouse | Mouse MSH3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-SE1464-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque MSH3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-SE1464-Ag | Cat/Feline | Cat/Feline MSH3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-SE1464-Ag | Dog/Canine | Dog/Canine MSH3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-SE1464-Ag | Bovines/Cattle | Bovines/Cattle MSH3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-SE1464-Ag | Equine/Horse | Equine/Horse MSH3 recombinant protein | Mammalian cell | Detail |
